中国中药杂志

2020, v.45(22) 5429-5437

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中药有效成分调控细胞自噬的研究进展
Research progress on effective components of Chinese materia medica in regulating autophagy

王均琪;葛莎莎;张明烁;王斌;图雅;黄秀兰;李志勇;
WANG Jun-qi;GE Sha-sha;ZHANG Ming-shuo;WANG Bin;TU Ya;HUANG Xiu-lan;LI Zhi-yong;School of Pharmacy, Minzu University of China;Medical Experiment Center, China Academy of Chinese Medical Sciences;School of Pharmacy, Shannxi University of Traditional Chinese Medicine;Research Center of Traditional Chinese Medicine Development, China Academy of Chinese Medical Sciences;

摘要(Abstract):

自噬是一种进化上高度保守、多组分激活的能量代谢和自我更新的机制,在维持细胞内正常的生理状态发挥重要的调节作用,与多种疾病病理过程的发生发展密切相关。近年来中药有效成分通过调控细胞自噬防治肿瘤、神经退行性疾病、心血管疾病、代谢相关疾病、免疫相关疾病的机制研究取得了长足进展。该文概述了中药成分防治上述多种疾病的细胞自噬调控分子机制,发现目前中药单体调控肿瘤细胞、心血管细胞自噬报道相对较多,并以生物碱类、皂苷类、多酚类、黄酮类、天然萜类等结构类型为主;机制研究主要集中在依赖mTOR通路。调控细胞自噬已成为中药防治疾病新的研究靶向策略,该文为中药成分的科学有效性及其自噬调控优势提供证据,以期为中药在自噬领域的深入研究和天然自噬调节剂的开发提供参考。
Autophagy is a highly conservative and multi-component activated energy metabolism and self-renewal mechanism, which plays a crucial regulatory role in maintaining the normal physiological state of cells and is involved in various pathological processes. In recent years, the mechanism study has made great progress in regulating autophagy with effective components of Chinese materia medica(CMM),which are reported to prevent and treat cancers, neurodegenerative diseases, cardiovascular diseases and metabolic and immune-related diseases. This review outlines the molecular regulation mechanisms of cell autophagy with CMM components in controlling the above-mentioned diseases. There are many relevant reports on the regulatory mechanisms of autophagy in tumor and cardiovascular cells with CMM monomers. The main chemical structural types are alkaloids, saponins, polyphenols, flavonoids and terpenes. And m-TOR pathway is the main mechanism relating to the regulatory mechanisms of autophagy with CMM. Therefore, the regulatory mec-hanisms of cell autophagy become a new research targeting strategy of therapies with CMM. This review provides evidences for the effectiveness and scientificity of CMM in regulating autophagy, in the expectation of providing references for the in-depth studies of CMM in the field of autophagy and the development of natural autophagy regulators.

关键词(KeyWords): 自噬;中药有效成分;信号通路
autophagy;effective components of Chinese materia medica;singalling pathway

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81470182,81473797)

作者(Author): 王均琪;葛莎莎;张明烁;王斌;图雅;黄秀兰;李志勇;
WANG Jun-qi;GE Sha-sha;ZHANG Ming-shuo;WANG Bin;TU Ya;HUANG Xiu-lan;LI Zhi-yong;School of Pharmacy, Minzu University of China;Medical Experiment Center, China Academy of Chinese Medical Sciences;School of Pharmacy, Shannxi University of Traditional Chinese Medicine;Research Center of Traditional Chinese Medicine Development, China Academy of Chinese Medical Sciences;

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DOI: 10.19540/j.cnki.cjcmm.20200727.601

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