中国中药杂志

2020, v.45(21) 5129-5142

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藜芦属植物甾体生物碱及其药理活性研究进展
Advances in studies on steroidal alkaloids and their pharmacological activities in genus Veratrum

张蒙珍;高丽娟;徐世芳;黄文康;李晓誉;叶益萍;
ZHANG Meng-zhen;GAO Li-juan;XU Shi-fang;HUANG Wen-kang;LI Xiao-yu;YE Yi-ping;Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Institute of Materia Medica,Hangzhou Medical College;

摘要(Abstract):

藜芦属植物含有多种甾体生物碱成分,目前从该属植物中分离鉴定了至少184个甾体生物碱,其中西藜芦碱型69个(A-1~A-69),藜芦胺型21个(B-1~B-21),介藜芦碱型31个(C-1~C-31),茄次碱型10个(D-1~D-10)和维藜芦碱型53个(E-1~E-53)。研究表明这些甾体生物碱具有多种药理活性,主要包括降血压、抗血小板聚集和抗血栓形成、抗炎镇痛和抗肿瘤作用。该文对藜芦属植物中184个甾体生物碱进行分类归纳,并概述了其主要的药理活性,为藜芦属生物碱成分的开发和利用提供科学依据。
Genus Veratrum plants contain a diversity of steroidal alkaloids, so far at least 184 steroidal alkaloids attributed to cevanine type(A-1~A-69), veratramine type(B-1~B-21), jervanine type(C-1~C-31), solanidine type(D-1~D-10) and verazine type(E-1~E-53), respectively, have been isolated and identified in the genus Veratrum. Their pharmacological activities mainly focused on decreasing blood pressure, anti-platelet aggregation and anti-thrombosis, anti-inflammatory and analgesic, and antitumor effect. This paper classified and summarized the 184 kind of steroidal alkaloids from the Veratrum plants and their major pharmalogical activities in order to provide the scientific basis for the further development and utilization of active alkaloids.

关键词(KeyWords): 藜芦属;甾体生物碱;化学成分;药理活性
genus Veratrum;steroidal alkaloids;chemical constituents;pharmalogical activities

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金青年基金项目(81803404)

作者(Author): 张蒙珍;高丽娟;徐世芳;黄文康;李晓誉;叶益萍;
ZHANG Meng-zhen;GAO Li-juan;XU Shi-fang;HUANG Wen-kang;LI Xiao-yu;YE Yi-ping;Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Institute of Materia Medica,Hangzhou Medical College;

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DOI: 10.19540/j.cnki.cjcmm.20200612.201

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