中国中药杂志

2012, v.37(07) 934-936

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膜分离技术应用于川芎茶调颗粒提取工艺研究
Application of membrane separation technology in extraction process of Chuanxiong Chatiao granules

张丽艳;梅基雄;谢宇;李孟林;刘德江;何长青;
ZHANG Liyan1*,MEI Jixiong1,XIE Yu2,LI Menglin2,LIU Dejiang2,HE Changqing1(1.Guiyang College of Traditional Chinese Medicine,Guiyang 550002,China; 2.Guizhou Warmen Pharmaceutical Co.,Ltd.,Guiyang 550018,China)

摘要(Abstract):

目的:将膜分离技术应用于川芎茶调颗粒浓缩工艺中,为实现川芎茶调颗粒膜浓缩产业化应用奠定一定的研究基础。方法:应用单因素方法对膜型号、过膜压力、过膜温度、膜的清洗方式进行了优选,并对新工艺与传统工艺制备的川芎茶调提取物的质量进行了对比。结果:优选出的最佳工艺为采用SMN-130A2350054膜、在浓缩压力1.7 MPa,浓缩温度36℃时,对川芎茶调颗粒提取液进行浓缩;采用1%多聚磷酸钠为清洗剂,对过滤后的膜进行清洗。分别采用膜工艺及传统工艺制备川芎茶调提取物质量一致。结论:优选出的膜工艺条件稳定、可行,能有效的实现浓缩和节能效果,生产出的川芎茶调颗粒提取物的质量与传统工艺一致,为其产业化应用提供一定的研究依据。
Objective: To apply the membrane separation process in the concentration process of Chuanxiong Chatiao granules and to lay the foundation for its industrialized application.Method: The type of membrane,the optimal pressure,the optimal temperature and the optimal detergent were selected by the single factor method.A comparative study was conducted between qualities of extracts from Chuanxiong Chatiao granules by new and traditional processes.Result: The type of membrane was determined to be SMN-130A2350054.The optimal pressure was 1.7 MPa.The optimal temperature was 36 ℃ and the optimal detergent was 1% sodium polyphosphate.The qualities of extracts from Chuanxiong Chatiao granules by new and traditional processes showed no difference.Conclusion: The selected membrane separation process can effectively achieve concentration and save energy.The extracts from Chuanxiong Chatiao granules by the new process show no difference with traditional processes.Therefore,it provides basis for the industrialized application of Chuanxiong Chatiao granules.

关键词(KeyWords): 川芎茶调颗粒;膜浓缩;阿魏酸;甘草酸
Chuanxiong Chatiao granules;membrane concentration;ferulic acid;glycyrrhizic acid

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基金项目(Foundation): 贵州省科技厅火炬项目(黔科合高字[2010]5004);; 贵阳市乌当区科学技术计划项目([2010]乌科技合同字第066号)

作者(Author): 张丽艳;梅基雄;谢宇;李孟林;刘德江;何长青;
ZHANG Liyan1*,MEI Jixiong1,XIE Yu2,LI Menglin2,LIU Dejiang2,HE Changqing1(1.Guiyang College of Traditional Chinese Medicine,Guiyang 550002,China; 2.Guizhou Warmen Pharmaceutical Co.,Ltd.,Guiyang 550018,China)

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