中国中药杂志

2007, (04) 285-288+326

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地高辛血药浓度检测方法的分析
Analysis of detecting methods of digoxin blood drug level

李优鑫;毛静远;李惠芬;
LI You-xin~(1),MAO Jing-yuan~(2),LI Hui-fen~(1)(1.Pharmacy college,Tianjin medical university,Tianjin 300070,China;2.The first attached hospital,Tianjin university traditional Chinese medicine, Tianjin 300193,China)

摘要(Abstract):

地高辛在临床上主要用于治疗充血性心力衰竭,其治疗量和中毒量非常接近,有时甚至出现交叉、重叠,而且血药浓度影响因素极多,药效学和药动学个体差异大。为达到治病和防止中毒的目的,对其进行血药浓度监测必不可少。结合国内外地高辛血药浓度监测方法,包括放射免疫分析法、酶免疫分析法、化学发光、荧光等免疫技术和液质联用技术等,从灵敏度、线性范围、交叉反应、精密度等方面总结了各种方法的特点。放射免疫分析法以其价格低廉,酶免疫分析法以特异性强,化学发光免疫分析法以灵敏度高、稳定性好,荧光偏振免疫分析法以其灵敏度高、方法简便,液相-质谱联用分析法以分辨率高、专属性强等优点而受到广大使用者的青睐。将两种或两种以上方法优势互补、有机结合、综合利用是今后主要发展趋势之一。
Digoxin plays a part in healing of congestive heart failure in clinic.Its therapeutic dose is very approximate to toxic dose and even they overlap each other sometimes.There are many influencing factors on blood drug level of digoxin.Pharmacodynamics and pharmacokinetics varies with different individuality.It is indispensable to detecting blood drug level in order to treat disease and prevent intoxication.Integrating with the detecting-methods of blood drug level of digoxin home and broad,characteristic of many methods are summarized from sensitivity,linearity range,cross-reaction and precision.These methods include radio immunoassay,enzyme immunoassay,chemiluminescence immunoassay,fluorescence immunoassay and HPLC-MS-MS.These methods are popular for theirspecialized ascendancy.The cost of radio immunoassay is low.Enzyme immunoassay has good specificity.Sensitivity and stability of chemiluminescence immunoassay is very excellent.Fluorescence polarization immunoassay is sensitive and convenient.HPLC-MS-MS has high resolution and good specificity.One of the development tendencies is to combine two or more methods in detecting the blood drug level of digoxin which contribute to these methods integrated use.

关键词(KeyWords): 地高辛;血药浓度;检测方法;分析
digoxin;blood drug level;detecting methods;analysis

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基金项目(Foundation): 国家自然科学基金资助项目(30371752))

作者(Author): 李优鑫;毛静远;李惠芬;
LI You-xin~(1),MAO Jing-yuan~(2),LI Hui-fen~(1)(1.Pharmacy college,Tianjin medical university,Tianjin 300070,China;2.The first attached hospital,Tianjin university traditional Chinese medicine, Tianjin 300193,China)

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