刘友平,宋英,秦春梅,张家明
LIU You-ping1, SONG Ying2, QIN Chun-mei1, ZHANG Jia-ming2 (1.Chengdu University of TCM, Chengdu 610075, Sichuan, China; 2.The Affiliated Hospital of Chengdu University of TCM,Chengdu 610075, Sichuan, China)

• 1:成都中医药大学
• 2:成都中医药大学附属医院
• 3:成都中医药大学
• 4:成都中医药大学附属医院 四川成都610075

摘要(Abstract)：

目的 :建立枳实导滞浓缩丸的质量标准。方法 :采用TLC对处方中的大黄、枳实、黄连、黄芩进行定性鉴别 ;用HPLC法测定方中君药大黄中大黄素的含量。结果 :在TLC色谱中 ,能检出大黄、枳实、黄连、黄芩 ;大黄素在 0 .0 6 12～ 0 .6 12 0 μg与峰面积积分值呈良好的线性关系 ,r =0 .9999,平均回收率 97.9% ,RSD =2 .1%。结论 :所建立的方法对方中 4味药材能准确、快速地进行定性、定量检测 ,可用于枳实导滞浓缩丸的质量控制。
Objective:To develop the quality control standard of Zhishidaozhi Tabloid Pills. Method: Applying TLC to indentify Radix et Rhizoma Rhei,Fructus Aurantii Immaturus,Rhizoma Coptidis ,Radix Scutellariae ,and HPLC to determine the content of emodin of Radix et Rhizoma Rhei. Result:Radix et Rhizoma Rhei ,Fructus Aurantii Immaturus,Rhizoma Coptidis and Radix Scutellariae could be indentified by TLC. Emodin showed a good linear relationship at a rang of 0.0612～0.612 μg, r=0.9999. The average recovery was 97.9 %, and RSD was 2.1%. Conclusion:The methods are accurate and quick ,and can be used for the quality control of Zhishidaozhi Tabloid Pills.

关键词(KeyWords)： 枳实导滞浓缩丸;TLC;HPLC;大黄素
Zhishidaozhi Tabloid Pills ; TLC; HPLC;emodin

Abstract:

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基金项目(Foundation):

作者(Author): 刘友平,宋英,秦春梅,张家明
LIU You-ping1, SONG Ying2, QIN Chun-mei1, ZHANG Jia-ming2 (1.Chengdu University of TCM, Chengdu 610075, Sichuan, China; 2.The Affiliated Hospital of Chengdu University of TCM,Chengdu 610075, Sichuan, China)

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参考文献(References)：

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• [4]　张传仙.反相高效液相色谱法测定外用I号液中大黄素的含量.时珍国医国药,2000,11(7):611.