中国中药杂志

2003, (04)

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知母、黄芪对小鼠实验性心肌肥厚及应激反应能力的影响
Effect of Zhimu and Huangqi on Cardiac Hypertrophy and Response to Stimulation in Mice

胡宇驰,侯家玉
HU Yu chi, HOU Jia yu(Beijing University of Chinese Pharmacology and Medicine, Beijing 100102, China)

摘要(Abstract):

目的 :研究知母、黄芪对心率加快和心肌肥厚的作用 ,观察知母减慢心率、提高运动耐量和对应激反应的能力 ,以探讨清热滋阴药知母是否能用于心衰的治疗。方法 :①小鼠腹腔注射盐酸异丙肾上腺素 (ISO)注射液 ,测定心率加快作用和给予知母、黄芪后对心率加快的拮抗作用。②小鼠每天 2次皮下注射盐酸异丙肾注射液造心肌肥厚模型 ,给药 1 4d后测定各组小鼠的心重指数。③小鼠行腹主动脉结扎术 ,造模 3个星期 ,观察给药 2周后各组小鼠的心重指数和跑步能力 ,测定清醒态心率和腹腔注射异丙肾 5min后小鼠心率。④小鼠每天 2次皮下注射盐酸异丙肾注射液连续 1 4d(给药 1 2d)造心肌肥厚模型 ,观察各组小鼠在冷 (- 2 0℃ )和热 (45℃ )刺激下的死亡率和死亡时间。结果 :知母能拮抗异丙肾上腺素致小鼠心率加快的作用 ,降低心肌肥厚小鼠心重指数 ,表明有一定的拮抗儿茶酚胺的作用 ;并能降低腹主动脉结扎小鼠清醒态心率并增强跑步能力。知母合用黄芪还能显著提高腹主动脉结扎小鼠对异丙肾的反应能力 ,降低异丙肾造模小鼠冷热刺激条件下的死亡率并延长死亡时间。结论 :知母、黄芪合用能减慢心率 ,提高心肌储备 ,改善实验性心肌肥厚小鼠对应激反应的能力
Objective:To observe the effect of Zhimu and Huangqi on increasing heart rate and cardiac hypertrophy,and its bradycardia effect,to evaluate the exercise capacity and response to stimulation and to discuss the use of Zhimu in treating heart failure. Method: ① Rats were treated with isoproterenol 1.25 μg·kg -1 ip,and then the increasing of heart rate and the bradycardia effect were measured after administrated with Zhimu or Huangqi for 3 days. ② Mice cardiac hypertrophy model was established by s.c ISO 1 mg·kg -1 , 2 times per day for 14 days and heart weight index was measured after Zhimu and Huangqi was given orally alone or jointly for 14 days. ③ Abdominal aorta banding operation was done in mice and 3 weeks after operation,they were administrated for 2 weeks,and then run time(exercise capacity), quiet heart rate, ISO response heart rate after ip isoproterenol and heart weight index were measured. ④ Cardiac hypertrophy model (inject ISO 14 days) mice were administrated for 12 days, and the mortality and dying time of mice in cold (-20 ℃) and heat(45 ℃) stimulative condition were observed. Result: Zhimu could cut down the increasing of heart rate induced by ISO, decrease significantly heart weight index in cardiac hypertrophy mice, reduce the quiet heart rate and prolong the run time in abdominal banding model. Zhimu combined with Huangqi could also improve the ISO response in abdominal banding model mice, reduce the mortality and delay dying time of mice in stimulative condition. Conclusion: Zhimu combined with Huangqi can slow down heart rate, enhance the reserve force of the heart,and improve the response capacity of cardiac hypertrophy mice in stimulative condition.[

关键词(KeyWords): 知母;黄芪;心肌肥厚;心率;应激反应
Zhimu; Huangqi; cardiac hypertrophy; heart rate; response to stimulation

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作者(Author): 胡宇驰,侯家玉
HU Yu chi, HOU Jia yu(Beijing University of Chinese Pharmacology and Medicine, Beijing 100102, China)

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