耿洪娇;谢雁鸣;张敏;
GENG Hong-jiao;XIE Yan-ming;ZHANG Min;Institute of Basic Reserach in Clinical Medicine, China Academy of Chinese Medical Sciences;School of Statistics, Renmin University of China;

• 1:中国中医科学院中医临床基础医学研究所
• 2:中国人民大学统计学院

摘要(Abstract)：

该研究运用Tabu搜索算法,对真实世界醒脑静注射液治疗颅脑损伤及合并症的联合用药情况进行群组模块分析,筛选归纳出醒脑静注射液治疗颅脑损伤及合并症的临床联合用药组合方案。包括颅脑损伤伴意识障碍者,考虑应用醒脑静注射液+纳美芬+胞磷胆碱;合并脑水肿、神经损伤,考虑应用甘露醇/甘油果糖/呋塞米+单唾酸四己糖神经节苷脂钠;合并肺部感染,考虑应用醒脑静注射液+喜炎平+盐酸氨溴索+痰热清注射液;并发休克,考虑应用羟乙基淀粉+盐酸多巴胺/盐酸多巴酚丁胺+碳酸氢钠。体现了中西药联合治疗为特点的用药组合,以上用药方案仅供临床医师参考,临床应用需根据患者具体病情,结合临床获益与风险选择用药,注意配伍禁忌。进一步可在该研究基础上,针对某种子群模块开展前瞻性临床疗效和安全性评价。
In this study, Tabu search algorithm was used to analyze the drug combination of Xingnaojing Injection in the treatment of brain injury and complications in the real world, and the clinical drug combination of Xingnaojing Injection in the treatment of brain injury and complications was selected and summarized. The combination of Xingnaojing Injection, Namefen and Citicoline were recommended in the treatment of brain injury and complications. For brain edema and nerve injury, Mannitol/Glycerol Fructose/Furosemide+Tetrahexose Monosialate Ganglioside Sodium should be recommended. For those with pulmonary infection, Xingnaojing Injection+Xiyanping+Ambroxol Hydrochloride+Tanreqing Injection should be recommended. For those with shock, Hydroxyethyl Starch+Dopamine Hydrochloride/Dobutamine Hydrochloride+Sodium Bicarbonate should be recommended. The combination reflected the characteristics of Chinese and Western medicine. The above medication regimen was only for clinicians′ reference. The clinical application should be based on patients′ specific conditions, clinical benefits and risks, as well as the incompatibility. On the basis of the findings, further studies can be carried out for prospective clinical efficacy evaluation and safety evaluation for a specific subgroup module.

关键词(KeyWords)： 醒脑静注射液;颅脑损伤;真实世界;联合用药;Tabu搜索算法
Xingnaojing Injection;craniocerebral injury;real world;combined medication;Tabu search algorithm

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划项目(2018YFC1707400)

作者(Author): 耿洪娇;谢雁鸣;张敏;
GENG Hong-jiao;XIE Yan-ming;ZHANG Min;Institute of Basic Reserach in Clinical Medicine, China Academy of Chinese Medical Sciences;School of Statistics, Renmin University of China;

Email:

DOI: 10.19540/j.cnki.cjcmm.20200325.501

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