中国中药杂志

2015, v.40(06) 1044-1047

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绿原酸及其肠道代谢产物对中枢神经系统疾病的作用和机制研究进展
Recent progress of potential effects and mechanisms of chlorogenic acid and its intestinal metabolites on central nervous system diseases

邢丽娜;周明眉;李云;石晓雯;贾伟;
XING Li-na;ZHOU Ming-mei;LI Yun;SHI Xiao-wen;JIA Wei;Center for Chinese Medical Therapy and Systems Biology,Shanghai University of Traditional Chinese Medicine;

摘要(Abstract):

绿原酸具有抗菌、抗病毒、清除自由基和兴奋中枢神经系统等多种生物活性。然而绿原酸仅有约1/3直接吸收入体内,其生物活性更多地是依靠其肠道代谢产物发挥效应得以实现。因此,研究绿原酸对中枢神经系统疾病的作用,有必要结合其肠道代谢产物的相关活性。该文结合近年来关于绿原酸的肠道代谢研究结果,综述了绿原酸及肠道代谢产物对于中枢神经系统疾病的潜在作用和作用机制,为进一步提高其应用价值提供依据。
Chlorogenic acid displays several important roles in the therapeutic properties of many herbs,such as antioxidant activity,antibacterial,antiviral,scavenging free radicals and exciting central nervous system. Only about one-third of chlorogenic acid was absorbed in its prototype,therefore,its gut metabolites play a more important role in the therapeutic properties of chlorogenic acid. It is necessary to consider not only the bioactivities of chlorogenic acid but also its gut metabolites. This review focuses on the potential activities and mechanisms of chlorogenic acid and its gut metabolites on central nervous system diseases.

关键词(KeyWords): 绿原酸;肠道代谢产物;中枢神经系统疾病
chlorogenic acid;gut metabolites;central nervous system diseases

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基金项目(Foundation): 上海中医药大学预算内项目(2013JW17);; 上海中医药大学中药学一流学科创新研究基金项目(ZYX-CXYJ-018);; “085”一流学科建设科技创新支撑计划(引导创新计划085ZY1205);; 上海高校特聘教授(东方学者)岗位计划项目(2011-50)

作者(Author): 邢丽娜;周明眉;李云;石晓雯;贾伟;
XING Li-na;ZHOU Ming-mei;LI Yun;SHI Xiao-wen;JIA Wei;Center for Chinese Medical Therapy and Systems Biology,Shanghai University of Traditional Chinese Medicine;

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