中国中药杂志

2019, v.44(02) 218-223

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基于药性组合的活血化瘀中药的辛苦味性效关系研究
Nature-effect relationship research between pungent and bitter taste of traditional Chinese medicine for promoting blood circulation and removing blood stasis based on nature combination

刘敏;吴东雪;李晶;候宁;张燕玲;乔延江;
LIU Min;WU Dong-xue;LI Jing;HOU Ning;ZHANG Yan-ling;QIAO Yan-jiang;State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine;

摘要(Abstract):

活血化瘀药是临床中最常用的一类药,多为辛、苦味,为了探讨活血化瘀药的药性与功效的内在联系,该研究利用TCMSP平台及Cytoscape 3. 5. 1平台构建温辛肝、温苦肝药性组合交补集蛋白互作网络及靶点疾病网络,并对其进行网络模块分析。结果表明,温肝网络与癌症、高血压、抑郁症等疾病有关,体现出温肝之温阳化气、行气活血、化瘀散结的功效。苦味网络与心肌梗死、癌症、炎症等疾病有关,体现出"苦"可宣泄宣通、泄通则瘀散的功效。辛味网络与癌症、心血管疾病、骨质疏松症等疾病有关,体现出辛味之活血、消散的功效。研究表明,温辛肝、温苦肝药性组合通过调节不同靶点参与不同疾病过程,从而达到活血化瘀的功效。
The herbs for promoting blood circulation and removing blood stasis were used commonly in clinical,and most of them are pungent and bitter. In order to study the nature-effect interrelationship of the herbs for promoting blood circulation and removing blood stasis,the TCMSP platform and Cytoscape 3. 5. 1 platform were used to construct warm-pungent-liver and warm-bitter-liver of the complement and intersection protein interaction network and the target-disease network and the network module was analyzed. As a result,warm-liver target-disease network is associated with diseases such as cancer,hypertension,and depression,which exerts the efficacy of warming Yang and transforming Qi,promoting Qi and activating blood,removing blood stasis and dispersing phlegm. The bitter taste target-disease network is associated with diseases such as myocardial infarction,cancer,inflammation and other diseases,which exerts the efficacy of dissipating the stasis. The pungent taste target-disease network is associated with diseases such as cancer,cardiovascular disease,osteoporosis and other diseases,which exerts the efficacy of invigorating the circulation of blood and eliminating stagnation. The research shows that the medicinal combination of warm-pungent-liver and warm-bitter-liver has the efficacy of promoting blood circulation and removing blood stasis by regulating different targets in different disease processes.

关键词(KeyWords): 药性组合;活血化瘀;靶点;疾病
nature combination;promoting blood circulation and removing blood stasis;target;disease

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金重点项目(81430094)

作者(Author): 刘敏;吴东雪;李晶;候宁;张燕玲;乔延江;
LIU Min;WU Dong-xue;LI Jing;HOU Ning;ZHANG Yan-ling;QIAO Yan-jiang;State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine;

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DOI: 10.19540/j.cnki.cjcmm.20181009.008

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