中国中药杂志

2015, v.40(08) 1493-1496

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pH对热毒宁栓中绿原酸、栀子苷体外直肠渗透性的影响
Study on effect of pH on rectum permeability of active ingredients in Reduning suppositories in vitro

闫明;韦迎春;孟瑾;徐殿红;吴云;萧伟;
YAN Ming;WEI Ying-chun;MENG Jin;XU Dian-hong;WU Yun;XIAO Wei;Jangsu Kanion Pharmaceutical Co.,Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;

摘要(Abstract):

目的:考察不同pH的热毒宁栓中绿原酸、栀子苷的直肠渗透特性。方法:制备4种不同pH的热毒宁栓,将其置于底部扎口的大鼠直肠中,以生理盐水作为接收液,进行直肠体外渗透性研究,并采用HPLC对接收液中的绿原酸、栀子苷含量进行测定,绘制给药24 h的累积渗透曲线,渗透速率以及Q-t方程。结果:绿原酸的渗透量随着pH的增高呈下降趋势,栀子苷的渗透量平稳。结论:热毒宁栓的pH影响主要药效成分的直肠渗透吸收,在进行栓剂成型工艺研究时需要对产品的最优pH范围进行深入研究。
Objective:To investigate the effect of different pH on rectum permeability of chlorogenic acid and geniposide.Method:Four kinds of Reduning suppositories of different pH were separated and put into the rectum to study the suppositories in vitro and the content of chlorogenic acid and geniposidesamples was determined by HPLC to calculate the permeation in 24 hours.Result:With increase of pH within 2.5-7.4,the steady state flux of chlorogenic acid was increased,but the steady state flux of geniposidesamples was steady.Conclusion;Adjusted the pH can increase the rectum permeability of active ingredients in Reduning auppositories.

关键词(KeyWords): 栓剂;绿原酸;栀子苷;直肠渗透性;pH
suppositories;chlorogenic acid;geniposidesamples;phosphate buffer;rectum permeability;pH

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作者(Author): 闫明;韦迎春;孟瑾;徐殿红;吴云;萧伟;
YAN Ming;WEI Ying-chun;MENG Jin;XU Dian-hong;WU Yun;XIAO Wei;Jangsu Kanion Pharmaceutical Co.,Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;

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