中国中药杂志

2009, v.34(09) 1101-1103

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荜茇三氯甲烷部位化学成分研究
Chemical constituents from air-dried Piper longum

刘文峰;江志勇;陈纪军;张雪梅;马云保;
LIU Wenfeng1,2,JIANG Zhiyong1,CHEN Jijun1,ZHANG Xuemei1,MA Yunbao1(1.State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650204,China;2.Graduate University of Chinese Acdemy of Sciences,Beijing 100039,China)

摘要(Abstract):

目的:对胡椒科植物荜茇Piper longum的化学成分进行研究。方法:荜茇用95%乙醇提取,依次用石油醚、三氯甲烷、正丁醇萃取,对三氯甲烷萃取部分采用各种柱色谱进行分离纯化,通过波谱数据分析(MS,1H-NMR,13C-NMR)进行结构鉴定。结果:从三氯甲烷萃取部分分离鉴定了13个化合物,其中6个酰胺类生物碱,3个倍半萜,4个其他类化合物。分别鉴定为:1-(3′,4′-methylenedioxyphenyl)-1E-tetradecene(1),3-(3′,4′-methylenedioxophenyl)-propenal(2),胡椒酸(piperoic acid,3),3′,4′-dihydroxy-biabola-1,10-diene(4),eudesm-4(15)-ene-1β,6α-diol(5),7-epi-eudesm-4(15)-ene-1′,6β-diol(6),几内亚胡椒胺(guineesine,7),胡椒碱(piperine,8),胡椒酰胺(pipericide,9),2E,4E-dienamide(10),(2E,4E,8E)-N-isobutylhenicosa-2,4,8-trienamide(11),荜茇眀碱(piperlonguminine,12),胡椒酸甲酯(methyl piperate,13)。结论:其中化合物1~6为首次从荜茇中分离得到。
Objective: To study the chemical constituents of Piper longum.Method: The whole plant of air-dried P.longum.was extracted with 95% EtOH.The EtOH extract was suspended in H2O and extracted with petroleum ether,CHCl3 and n-BuOH,successively.The compounds were isolated and purified by column chromatography from the CHCl3 fraction,and identified based on spectral analyses(MS,1H-NMR,13C-NMR).Result: Threeteen compounds were isolated from P.longum,and were characterized as 1-(3′,4′-methylenedioxyphenyl)-1E-tetradecene(1),3-(3′,4′-methylenedioxophenyl)-propenal(2),piperoic acid(3),3′,4′-dihydroxy-biabola-1,10-diene(4),eudesm-4(15)-ene-1β,6α-diol(5),7-epi-eudesm-4(15)-ene-1β,6β-diol(6),guineesine(7),piperine(8),pipericide(9),2E,4E-dienamide(10),(2E,4E,8E)-N-isobutylhenicosa-2,4,8-trienamide(11),piperlonguminine(12),methyl piperate(13),Conclusion: Compounds 1-6 were obtained from P.longum for the first time.

关键词(KeyWords): 荜茇;酰胺类生物碱;倍半萜
Piper longum;amides;sesquiterpenes

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基金项目(Foundation): 云南省自然科学基金项目(312007C090M)

作者(Author): 刘文峰;江志勇;陈纪军;张雪梅;马云保;
LIU Wenfeng1,2,JIANG Zhiyong1,CHEN Jijun1,ZHANG Xuemei1,MA Yunbao1(1.State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650204,China;2.Graduate University of Chinese Acdemy of Sciences,Beijing 100039,China)

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