中国中药杂志

2006, (14) 1172-1175

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四物汤对环磷酰胺致血虚证小鼠骨髓蛋白质组的影响
Effects of Siwu decoction on bone marrow protein expression of blood deficiency mice induced by cyclophosphamide

刘丽丽;马增春;王宇光;秦红霖;谭洪玲;肖成荣;高月;
LIU Li-li,MA Zeng-chun,WANG Yu-guang,QIN Hong-lin,TAN Hong-ling,XIAO Cheng-rong,GAO Yue(Institute of Radiation Medicine,Beijing 100850,China)

摘要(Abstract):

目的:研究四物汤对环磷酰胺(CTX)损伤致血虚证小鼠骨髓蛋白质组的影响,旨在分子水平上探讨四物汤促进骨髓造血的作用机制。方法:采用CTX 250 mg.kg-1腹腔注射制成化学损伤型血虚证小鼠模型,利用蛋白质组学技术研究四物汤治疗后的差异蛋白质组。结果:研究发现CTX使小鼠骨髓中12个蛋白表达上调、3个蛋白表达下调,四物汤可使CTX造模后这些表达改变的蛋白有不同程度恢复。结论:四物汤可能通过影响与细胞凋亡、造血干祖细胞增殖分化有关的蛋白质而促进骨髓造血。
Objective: To study the effects of Siwu decoction on protein expression of blood deficiency mice induced by cyclophosphamide(CTX) and discuss the possible molecular mechanism on blood enriching function of Siwu decoction.Method: Blood deficiency mice were established by injecting ip with 250 mg·kg(-1) CTX.Proteomic technologics were applied to identify the different protein.Result: Siwu decoction could restore the changes of 12 up-regulated and 3 down-regulated proteins in bone marrow of blood deficiency mice induced by cyclosphosphamide.Conclusion: Siwu decoction could effect expression of proteins which functions including apoptosis,proliferation and differentiation of the haematopoietic stem/progenitor cell.The regulation in the molecular level might be the mechanism of stimulating hematopoiesis in bone marrow fo siwu decocetion.

关键词(KeyWords): 四物汤;CTX;骨髓;蛋白质组学
Siwu decoction;cyclosphosphamide;bone marrow;proteomics

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(30371725)

作者(Authors): 刘丽丽;马增春;王宇光;秦红霖;谭洪玲;肖成荣;高月;
LIU Li-li,MA Zeng-chun,WANG Yu-guang,QIN Hong-lin,TAN Hong-ling,XIAO Cheng-rong,GAO Yue(Institute of Radiation Medicine,Beijing 100850,China)

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