杜守颖;张倩怡;陆洋;翟永松;吴清;
DU Shouying,ZHANG Qianyi,LU Yang,ZHAI Yongsong,WU Qing (School of Chinese Pharmacy,Beijing University of Traditional Chinese Medicine,Beijing 100102,China)

• 1:北京中医药大学中药学院

摘要(Abstract)：

目的:考察醒脑静处方中艾片、麝香、郁金及合方后对栀子提取物肠吸收的影响。方法:采用大鼠在体肠吸收模型研究方中不同配伍条件下栀子提取物有效成分栀子苷的肠吸收情况。结果:栀子提取物质量浓度为0.8g·L-1(含栀子苷0.311g·L-1)时栀子苷吸收速率常数为(0.055±0.006)h-1(以栀子苷计);栀子提取物分别与艾片、郁金、麝香配伍时吸收速率常数分别为(0.072±0.010),(0.060±0.001),(0.066±0.008)h-1,合方后吸收速率常数为(0.076±0.011)h-1。经统计学分析,单味栀子组与配伍艾片组的吸收速率常数间有显著性差异(P=0.03),与配伍郁金和配伍麝香组的吸收速率常数间无显著性差异,与复方组的吸收速率常数间有显著性差异(P=0.02)。结论:配伍艾片及复方给药时可以显著促进栀子提取物中栀子苷的肠吸收。
Objective:To observe the influence of ingredients in Xingnaojing,such as moschus,borneol and radix curcumae on intestine absorption kinetics of gardenia extract. Method:An in situ intestinal perfusion model of rats was employed to investigate the absorption of geniposide in gardenia extract. Result:While gardenia extract was administered solely,the absorptive rate constant (K) of geniposide was (0.055±0.006) h-1; But while the extract was co-administered with radix curcumae,moschus and borneol,the K were (0.060±0.001),(0.066±0.008),(0.072±0.010) h-1,respectively. The K was(0.076±0.011) h-1 while the extract in total formulation for Xingnaojing. Conclusion:The K,while the extract is co-administered with borneol or total formulation is significantly higher than solely used. Borneol and complex prescription can significantly increase the intestinal absorption of geniposide in gardenia extract.

关键词(KeyWords)： 醒脑静;栀子提取物;肠吸收;艾片;麝香;郁金
gardenia extract; in situ intestinal perfusion model; borneol; moschus; radix curcumae

Abstract:

Keywords:

基金项目(Foundation): 科技部“重大新药创制”科技重大专项(2009ZX09502-008)

作者(Author): 杜守颖;张倩怡;陆洋;翟永松;吴清;
DU Shouying,ZHANG Qianyi,LU Yang,ZHAI Yongsong,WU Qing (School of Chinese Pharmacy,Beijing University of Traditional Chinese Medicine,Beijing 100102,China)

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参考文献(References)：

• [1]李瑾翡,王宁生,陆惠文.麝香酮药代动力学研究[J].中药新药与临床药理,2000,11(4):208.
• [2]黄天来,叶少梅,欧卫平,等.单剂量艾片及单剂量复方制剂中艾片的药物动力学比较研究[J].中药新药与临床药理,2006,17(4):265.
• [3]张倩怡,杜守颖,陆洋,等.栀子提取物中栀子苷油水分配系数及大鼠肠吸收动力学研究[J].中国中药杂志,2009,34(13):37.
• [4]胡一桥,郑梁元,钱陈钦,等.离子型药物酚红的小肠吸收研究[J].中国药科大学学报,1996,27(6):355.