中国中药杂志

2003, (12)

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人参皂苷Rg_2对大鼠化学性心肌缺血的影响
Effect of Ginsenoside Rg_2 on Chemical Myocardial Ischemia in Rats

田建明,李浩,叶金梅,郭伟芳,李龙云,王力平
TIAN Jian-ming, LI Hao, YE Jin-mei, GUO Wei-fang, LI Lon-yun, WANG Li-ping (Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province,Changchun 130021, Jilin, China)

摘要(Abstract):

目的 :观察人参皂苷Rg2 对化学性心肌缺血的保护作用。方法 :采用异丙肾上腺素、亚硝酸钠、垂体后叶素制备大鼠心肌缺血模型 ,iv给予人参皂苷Rg2 2 .5~ 10 .0mg·kg-1,观察心电图及心肌病理变化。结果 :人参皂苷Rg2 能明显抑制心电图S T段J点偏移 ,减小心肌坏死面积 ,降低肌酸激酶 (CK)、过氧化脂质 (MDA)含量 ,升高超氧化物歧化酶 (SOD)。结论 :人参皂苷Rg2 对大鼠心肌缺血有明显改善作用。
Objective: To investigate the protective effect of Ginsenoside Rg_2 on Chemical myocardial ischemia. Method: The models of myocardial ischemia were built in rats with isoproterenol,sodium nitrite,pituitrin. Ginsenoside Rg_2(iv 2.5, 5.0, 10.0 mg·kg -1 ) were intravenously administered. Result: Ginsenoside Rg_2 could improve the abnormal electrocardiogram(ECG),reduce the arca of myocardial ischemia and improve the abnormal zymologic value of myocardial. Conclusion: Ginsenoside Rg_2 has inhibitory function on myocardialischemia.

关键词(KeyWords): 人参皂苷Rg2;心肌缺血
ginsenoside Rg_2;myocardial ischemia

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基金项目(Foundation): 国家科委 95期间 10 3 5工程项目 (96 90 1 0 1 12 )

作者(Author): 田建明,李浩,叶金梅,郭伟芳,李龙云,王力平
TIAN Jian-ming, LI Hao, YE Jin-mei, GUO Wei-fang, LI Lon-yun, WANG Li-ping (Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province,Changchun 130021, Jilin, China)

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