中国中药杂志

2006, (20) 1715-1719

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毛细管电泳法研究板蓝根水提物抗流感病毒的作用机制
Mechanism study of anti-influenza effects of Radix Isatidis water extract by red blood cells capillary electrophoresis

陈智伟;吴灵威;刘树滔;蔡春平;饶平凡;柯李晶;
CHEN Zhi-wei~(1),WU Ling-wei~(1),LIU Shu-tao~(1),CAI Chun-ping~(2),RAO Ping-fan~(1),KE Li-jing~(1)(1.Institute of Biotechnology,Fuzhou University,Fuzhou 350002,China;2.Technology Centre of Fujian Entry-Exit Inspection and Quarantine Bureau,Fuzhou 350002,China)

摘要(Abstract):

目的:探讨板蓝根水提物抑制H1N1型流感病毒细胞结合活力的机制。方法:显微镜检判定板蓝根不同处理方式下的红细胞经流感病毒侵染后的形态学差异,通过毛细管电泳结合显微镜镜检、血凝滴度指标进一步阐述板蓝根抗流感病毒的生化机制。结果:经过板蓝根保护过的细胞,能阻止病毒对细胞的吸附,推测其可能是通过与细胞膜的作用来保护细胞。结论:板蓝根通过结合到细胞膜上而起到保护细胞的作用,有效抑制了流感病毒对细胞的结合,从而达到抗病毒的目的。
Objective: To research the mechanism of the inhibition effects of BWE on cell attachment of influenza virus by capillary electrophoresis.Method: The morphologic difference of red cells after treating with BWE infected by influenza virus was detected with microscope,capillary electrophoresis and HA.Result: The pretreatment of the normal cells with BWE inhibited the attachment of influenza to the cells,while no meaningful inhibition was observed when influenza virus was pretreated before being inoculated to cells.Conclusion: The results indicate that the inhibition effects of BWE on cell attachment of influenza virus may be an important mechanism of anti-influenza activity of Radix Isatidis Extracts.

关键词(KeyWords): 板蓝根;红细胞;毛细管电泳;流感病毒;抗病毒
Isatidis Roots;red blood cell;capillary electrophoresis;influenza virus;antiviral mechanism

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作者(Author): 陈智伟;吴灵威;刘树滔;蔡春平;饶平凡;柯李晶;
CHEN Zhi-wei~(1),WU Ling-wei~(1),LIU Shu-tao~(1),CAI Chun-ping~(2),RAO Ping-fan~(1),KE Li-jing~(1)(1.Institute of Biotechnology,Fuzhou University,Fuzhou 350002,China;2.Technology Centre of Fujian Entry-Exit Inspection and Quarantine Bureau,Fuzhou 350002,China)

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