中国中药杂志

2004, (06)

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注射用柴胡挥发油脂质体制备工艺研究
Study on liposome prepration technique of Bupleurum chinense volatile oil for injection

禹玉洪,李雪春,吴涛,屠鹏飞
YU Yu-hong 1,2 ,LI Xue-chun 3,WU Tao 3,TU Peng-fei 4(1.The Postdoctoral Station of the Medical Center of Peking University, Beijing 100083, China;2.The Postdoctoral Work Station of the Yiling Pharmaceutical Group of Hebei Province, Shijiazhuang 050035, China;3.The National Institutes of Pharmaceutical Research and Development, Beijing 102206, China;4.Modern Research Center for Traditional Chinese Medicine,Peking University,Beijing 100083, China)

摘要(Abstract):

目的 :探讨将柴胡挥发油制成注射用脂质体的制备工艺可行性。方法 :通过研究柴胡挥发油脂质体的处方组成、挥发油包封率、冻干可行性以及二者的指纹图谱变化。结果 :柴胡挥发油的包封率为 81.9%。经冷冻干燥后 ,脂质体中被包封挥发油的保留率为 88.6 %。结论 :将柴胡挥发油制备成注射用脂质体在制备工艺上是可行的。
Objective:To study the prepration technique of the liposome of Bupleurum chinense volatile oil. Method: The composition,entrapement ratio of volatile oil,availability of freeze-drying and the changes of finger prints were studied. Result:Entrapement ratio reached 81.9%. After freeze-dried,the remaining ratio of the oil entraped in the liposome reached 88.6%. Conclusion: It is practicable to make B. chinense injection into freeze-dried liposome powder.

关键词(KeyWords): 柴胡挥发油;脂质体;制备工艺;冻干粉针
volatile oil;liposome;prepration technique;freeze-dried powder for injection

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作者(Author): 禹玉洪,李雪春,吴涛,屠鹏飞
YU Yu-hong 1,2 ,LI Xue-chun 3,WU Tao 3,TU Peng-fei 4(1.The Postdoctoral Station of the Medical Center of Peking University, Beijing 100083, China;2.The Postdoctoral Work Station of the Yiling Pharmaceutical Group of Hebei Province, Shijiazhuang 050035, China;3.The National Institutes of Pharmaceutical Research and Development, Beijing 102206, China;4.Modern Research Center for Traditional Chinese Medicine,Peking University,Beijing 100083, China)

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