中国中药杂志

2006, (24) 2070-2073

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健骨复方对去卵巢致骨质疏松症大鼠的治疗作用
Cure effects of Jiangu Fufang on osteoporotic model induced by ovariectomy

邓英贤;马增春;谭洪玲;肖成荣;王宇光;高月;
DENG Ying-xian~1 MA Zeng-chun~2 TAN Hong-ling~2 XIAO Cheng-rong~2 WANG Yu-guang~2 GAO Yue~2 (1.The General Hospital,the Air Force of the Chinese People's Liberation Army,Beifing 100036,China;2.Institute of Radiation Medicine Sciences,Academy of Military Medical Sciences,Beijing 100850,China)

摘要(Abstract):

目的:观察健骨复方对去卵巢致骨质疏松症大鼠的治疗作用。方法:切除双侧卵巢建立骨质疏松症大鼠模型,试验分正常对照组,假手术对照组,模型对照组,阳性药尼尔雌醇组和龙牡壮骨颗粒组,健骨复方低、中、高剂量组的剂量分别为3.25,6.5,13 g·kg(-1)。测定股骨密度、生物力学和骨形态学,同时测定用药后血清中钙、磷和碱性磷酸酶含量。结果:健骨复方灌胃给药3个月后可以升高大鼠股骨密度、最大弯曲力和弯曲强度,升高血清中钙、磷浓度,降低碱性磷酸酶浓度,同时可以升高大鼠腰椎骨小梁面积、骨小梁面积比、骨小梁平均厚度以及皮质骨厚度。结论:健骨复方通过增强骨密度、改善骨生物力学和骨代谢等途径对骨质疏松症有治疗作用。
Objective:To explore the cure effects of Jiangu Fufang on esteoporotic model induced by ovariectomy.Method: Rats were ovariectomized and administered drugs for 3 monthes.Bone mineral density and biomechanios properties,histomorphometric analysis and biochemical index such as calcium,phosphorus,alkaline phosphatnse were detected.Result:Jiangu Fufang could signifi- cantly increase bone density and biomechanios properties.The level of calcium,phosphorus and alkaline phosphatase were restored by Jiangn Fufang.Jiangu Fufang could significantly increase area of bone trabecula,thickness of cortical bone and bone trabecula.Con- clusion:Jiangn Fufang could cure osteoperosis through increasing bone mineral density,improving bone biomechanics properties,and effecting bone metabolism.

关键词(KeyWords): 健骨复方;骨质疏松;骨密度;生物力学
Jiangu Fufang;osteoporosis;bone mineral density;biomechanics

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作者(Authors): 邓英贤;马增春;谭洪玲;肖成荣;王宇光;高月;
DENG Ying-xian~1 MA Zeng-chun~2 TAN Hong-ling~2 XIAO Cheng-rong~2 WANG Yu-guang~2 GAO Yue~2 (1.The General Hospital,the Air Force of the Chinese People's Liberation Army,Beifing 100036,China;2.Institute of Radiation Medicine Sciences,Academy of Military Medical Sciences,Beijing 100850,China)

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