中国中药杂志

2005, (03)

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白松片对慢性应激抑郁小鼠模型行为学及脑内CRHmRNA表达的影响
The effects of Baisong tablet on the behaviors and CRHmRNA expression in the brain of rats following chronic stress

曹美群,胡随瑜,张春虎,王勇华
CAO Mei-qun, HU Sui-yu, ZHANG Chun-hu, WANG Yong-hua(Institute of Combined Traditional Chinese and Western Medicine, Xiangya Hospital,Central South University,Changsha 410008,China)

摘要(Abstract):

目的研究中药白松片对慢性应激小鼠行为学和脑内CRHmRNA表达的影响。方法采用不同应激因子交替持续应激21d复制小鼠慢性应激抑郁模型,观察小鼠体重增加情况和行为学指标,用逆转录聚合酶联反应(RTPCR)方法测定小鼠下丘脑和大脑皮质额叶CRHmRNA表达情况。结果与空白对照组相比,慢性应激模型组行为学明显处于抑郁状态,脑内CRHmRNA表达显著升高,体重增长显著缓慢;而中药白松片可显著改善行为学指标,体重增加较快,降低CRHmRNA表达。结论白松片具有抗抑郁作用,并可能与降低脑内CRHmRNA表达有关。
Objective: To investigate the effects of Baisong tablet on the behaviors and CRHmRNA expression in the chronic stress rats. Method: Rats were exposed to different ways of chronic stress. Body weight and behaviors were investigated during the whole procedure,the CRHmRNA expressions in the hypothalamus and prefrontal cortex were semiquantified by the RT-PCR method. Result: In comparision with the normal group,rats exposed to chronic stress showed decreased body weight and a significant reduction of consumption of sucrose solution, and the duration of immobility during the forced swimming test was increased significantly. The chronic stress rats was in depression of behavior. CRHmRNA expression in the brain of the chronic stress rats was upregulated significantly, while it was downregulated in the groups of Baisong tablet and the group of fluoxetin. Conclusion:Baisong tablet has the effect of antidepressant,and it may be related to the effect of the downregulated CRHmRNA expression in brain. [

关键词(KeyWords): 慢性应激;行为学;CRHmRNA;白松片;中药药效学
chronic stress;haviors; CRHmRNA;Baisong tablet;pharmacodynamics of traditional Chinese medicine Enhanced absorption of breviscapine photosomes in small intestine of ratsTANG Xiao-qiao~1 , YANG Xiang-liang~2 (1.Hubei Provincial Center for Disea

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基金项目(Foundation): 国家“十·五”科技攻关项目资助(2001BA701A22)

作者(Author): 曹美群,胡随瑜,张春虎,王勇华
CAO Mei-qun, HU Sui-yu, ZHANG Chun-hu, WANG Yong-hua(Institute of Combined Traditional Chinese and Western Medicine, Xiangya Hospital,Central South University,Changsha 410008,China)

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