中国中药杂志

2013, v.38(12) 2027-2032

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含人参中成药用药规律分析
Analysis on composition principles of Chinese patent drugs containing Ginseng

申丹;唐仕欢;卢朋;杨洪军;
SHEN Dan1,TANG Shi-huan1,LU Peng1,2,YANG Hong-jun1*(1.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China; 2.Institute of Automation,Chinese Academy of Sciences,Beijing 100190,China)

摘要(Abstract):

基于中医传承辅助平台(TCMISS),分析《中华人民共和国卫生部药品标准———中药成方制剂》(《中药部颁标准》)含人参方剂组方规律,为临床应用及新药研发提供参考。应用该平台V2.0软件,构建数据库,使用软件的统计报表模块,关联规则、改进的互信息法等数据挖掘方法,分析含有人参方剂中常用的药物、组合规则、核心组合。首先,通过对307首方剂的分析,总结明确人参常用药物组合45个,主治疾病24种。然后,基于人参的主治疾病,选择"心悸""健忘""胸痹"进行对比分析,比较人参治疗不同疾病的核心组合。发现《中药部颁标准》中含人参方剂所用药物多气血双补之功效,用药较为集中,组方法度清晰。此外,以3种疾病间的对比分析,反映了人参不同疾病用药规律和配伍特点,也为了"异病同治"提供理论支持。因此,中医传承辅助平台(V2.0)是中医用药规律分析的重要工具。纵横对比的方法,为研究临床用药规律提供了有效方法。
Use traditional Chinese medicine inheritance support system(TCMISS) to analyze the composition principles of Chinese patent drugs containing Renshen(Panax ginseng) in national standard for Chinese patent drugs(NSCPD) enacted by Ministry of Public Health of China.Via analyzing the regularity of prescriptions containing Ginseng which are recorded in NSCPD,to identify composition pattern and rule.Tweenty four drugs are used more than 50 times,in which,drugs that tonify qi and nourish flood have the highest frequency,and then medicines of liver and kidney tonifying,yin enriching and yang warming follow.Then 45 commonly used core combinations are analyzed via data mining methods such as association rules,improved mutual information method,etc.Meantime,three diseases,namely,palpitation,amnesia and chest discomfort are chosen from the 24 diseases that Ginseng most frequently used to make deeper analysis,which reflect the composition principle of Chinese patent drugs containing Ginseng.Therefore,TCMISS is an important tool in composition principle exploring of herbal formulae and meanwhile,the comparative analysis method contributes a lot to the exploration as well.

关键词(KeyWords): 人参;《中药部颁标准》;中医传承辅助平台;组方规律
Ginseng;national standard for Chinese patent drugs(NSCPD);traditional Chinese medicine inheritance support system(TCMISS);composition principle of prescription

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基金项目(Foundation): 国家“重大新药创制”科技重大专项(2009ZX09301-005);; 中医药行业科研专项(200907001-5)

作者(Author): 申丹;唐仕欢;卢朋;杨洪军;
SHEN Dan1,TANG Shi-huan1,LU Peng1,2,YANG Hong-jun1*(1.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China; 2.Institute of Automation,Chinese Academy of Sciences,Beijing 100190,China)

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