中国中药杂志

2010, v.35(03) 293-296

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大豆苷元-水溶性壳聚糖固体分散体的制备
Preparation of water-soluble chitosan solid dispersion of daidzein

葛月宾;王旭彬;郭伟林;谢晓敏;
GE Yuebin,WANG Xubin,GUO Weilin,XIE Xiaomin (School of Pharmacy,South-central University For Nationalities,Wuhan 430074,China)

摘要(Abstract):

目的:制备大豆苷元-水溶性壳聚糖固体分散体。方法:溶剂法制备不同比例的大豆苷元-水溶性壳聚糖固体分散体,进行体外溶出试验,差示扫描量热法、X-射线粉末衍射法、红外光谱法物相鉴别固体分散体的形成。结果:制备的1∶5和1∶9比例固体分散体中,60min时药物的累积溶出百分率高达90%以上,而对应的物理混合物累积溶出仅约40%,原药溶出仅34.8%。物相鉴定表明,大豆苷元一部分形成低共熔物,以微晶状态分散在固体分散体中。结论:以水溶性壳聚糖为载体制备的固体分散体,有效地提高了难溶性药物大豆苷元的溶出速率。
Objective:To enhance the dissolution rate of daidzein with solid dispersion technique. Method:Solid dispersions were prepared by the solvent method using water-solubility chitosan as a hydrophilic carrier. DSC,IR and X-ray methods were used to verify the formation of solid dispersion. Result:Dissolution percentages of solid dispersions were more than 90 percent in the drug-carrier ratio of 1∶5 and 1∶9. But dissolution percentages of physical mixtures and pure drug were 40 and 38.4 percent respectively. Part of daidzein dispersed in solid dispersion in the form of microcrystalline. Conclusion:Water-soluble chitosan solid dispersion can significantly increase dissolution rate of daidzein.

关键词(KeyWords): 大豆苷元;水溶性壳聚糖;固体分散体;溶出速率
daidzein; water-soluble chitosan; solid dispersion; dissolution rate

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基金项目(Foundation): 中南民族大学自然科学基金项目(YZZ06030)

作者(Author): 葛月宾;王旭彬;郭伟林;谢晓敏;
GE Yuebin,WANG Xubin,GUO Weilin,XIE Xiaomin (School of Pharmacy,South-central University For Nationalities,Wuhan 430074,China)

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