中国中药杂志

2003, (12)

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生化汤提取物对孕末期家兔子宫肌电活动的影响
Effect of Extract from Shenghua Decoction on Myoelectric Activity of Rabbit Uterine Muscle in the Latest Period of Pregnancy

洪敏,余黎,马骋,朱荃
HONG Min, YU Li, MA Cheng, ZHU Quan (National Standard Lab of Pharmacology for Chinese Materia Medica, Nanjing 210029, Jiangsu, China)

摘要(Abstract):

目的 :观察生化汤提取物对孕末期家兔子宫体及子宫颈肌电活动的影响 ,探讨其效应及作用方式。方法 :用PowerLab/8s生命信号记录仪采集乌拉坦麻醉状态下的怀孕末期家兔子宫体及子宫颈平滑肌肌电活动。结果 :生化汤提取物 4 0mg·kg-1能增加怀孕末期家兔子宫体的平滑肌动作电位脉冲的发放 (P <0 .0 1) ,对其子宫颈平滑肌肌电活动则无显著的影响 (P >0 .0 5 )。结论 :提示生化汤提取物具有增加宫体肌电活动作用 ,可以发挥催产、止血的效应 ;对宫颈的电活动无明显影响 ,表明它不干预产道舒缩 ,有利于胎儿的娩出。
Objective: To elucidate the difference between uterus body and cervix under the intervention of Shenghua decoction,and to observe the rabbit uterine muscle in the latest period of pregnancy for the way of myoelectric activity. Method: PowerLab/8s was used to record myoelectric activity of rabbit muscle in uterus body and cervix which was in a general anaesthesia state induced by urethane. Result: Myoelectric activities of rabbit uterine smooth muscle in the latest period of pregnancy was enhanced in vivo by being treated with Shenghua decoction 40 mg·kg -1 ( P <0.01) while cervix myoelectric activities had no significant change ( P <0.05). Conclusion: Myoelectric activities of rabbit uterine muscle in the latest period of pregnancy are enhanced by being treated with Shenghua decoction so its hemostatic effect can be represented via the constriction of uterus body.Shenghua decoction is beneficial for child delivery because cervix myoelectric activities have no significant change under the intervention of Shenghua decoction while the myoelectric activities of uterus body are increased significantly.

关键词(KeyWords): 子宫平滑肌肌电活动;生化汤
myoelectric activity; Shenghua decoction

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基金项目(Foundation): 国家科技部“十五”攻关项目 (99 92 9 0 3 0 6)

作者(Author): 洪敏,余黎,马骋,朱荃
HONG Min, YU Li, MA Cheng, ZHU Quan (National Standard Lab of Pharmacology for Chinese Materia Medica, Nanjing 210029, Jiangsu, China)

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