中国中药杂志

2010, v.35(17) 2250-2253

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骆驼蓬总生物碱提取物溶解性能表征方法的探讨
Investigation on representation methods of dissolubility property of total alkaloid extract from Peganum harmala

丁克敏;刘力;程雪梅;王长虹;王峥涛;
DING Kemin1,LIU Li1,CHENG Xuemei1,2,WANG Changhong1,2,WANG Zhengtao1,2 (1.Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine;Key Laboratory for Standardization of Chinese Medicines of Ministry of Education;Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines,Shanghai University of Traditional Chinese Medicine;Shanghai Key Laboratory for Compound Chinese Medicines,Shanghai 201210,China;2.Shanghai Research and Development Centre for Stan

摘要(Abstract):

目的:考察骆驼蓬总生物碱提取物在不同溶剂中的溶解性能,并对中药提取物溶解性的评价方法进行探讨。方法:分别采用沉淀法、指标成分测定法及粒径测定法测定骆驼蓬总生物碱提取物的溶解性及其在不同溶剂中的粒径分布情况。结果:骆驼蓬总生物碱提取物及其指标性成分骆驼蓬碱、去氢骆驼蓬碱在80%乙醇,95%乙醇及无水乙醇中均具有较好的溶解性,在60%乙醇中溶解性较差,在水中溶解性最差。骆驼蓬总生物碱提取物在不同溶剂中形成混悬液的粒径大小顺序为水>95%乙醇>无水乙醇>80%乙醇>60%乙醇。结论:骆驼蓬总生物碱提取物在80%以上的乙醇溶液中具有较好的溶解性。沉淀法和指标成分法测定结果具有一定的相关性;粒径测定法可提供提取物分散情况的信息;3种方法结合能较全面地反映中药提取物溶解性情况。
Objective: To investigate the representation methods of dissolubility property of total alkaloid extract from Peganum hamala in different solvents,and to investigate the evaluation method of the dissolubility property of extracts from traditional Chinese medicine.Method: The dissolubility property of the whole extract and markers of harmaline and harmine,as well as the particle diameter distribution of the extract in different solvents were evaluated by precipitation method,solubility test,and the particle diameter test.Result: Both the alkaloid extract and it′s index ingredients had good solubility in absolute ethanol,95% ethanol,and 80% ethanol,while the solubility in 60% ethanol was poor,and worst in water.The sequence of particle diameter of extract in solvents was in the following order water>95% ethanol>ethanol>60% ethanol>80% ethanol.Conclusion: The extract has good solubility in the ethanol solution whose concentration is over 80%.The results between precipitation method and index components method have certain correlation.The particle diameter method can provide distribution information of the extract in different solvents.Combination of those three methods could reflect the dissolubility property of extracts from traditional Chinese medicine more comprehensively.

关键词(KeyWords): 骆驼蓬;总生物碱提取物;溶解性;骆驼蓬碱;去氢骆驼蓬碱
Peganum harmala;total alkaloid extract;dissolubility property;harmaline;harmine

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基金项目(Foundation): 上海市基础研究重点项目(08JC1418600);; 上海市中药现代化专项(08DZ1972101)

作者(Author): 丁克敏;刘力;程雪梅;王长虹;王峥涛;
DING Kemin1,LIU Li1,CHENG Xuemei1,2,WANG Changhong1,2,WANG Zhengtao1,2 (1.Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine;Key Laboratory for Standardization of Chinese Medicines of Ministry of Education;Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines,Shanghai University of Traditional Chinese Medicine;Shanghai Key Laboratory for Compound Chinese Medicines,Shanghai 201210,China;2.Shanghai Research and Development Centre for Stan

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