中国中药杂志

2021, v.46(24) 6303-6311

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澜湄五国传统药用植物防治虫媒传染病研究概况
Traditional medicinal plants for arthropod-borne diseases of five countries in Lancang-Mekong region:a review

郝二伟;谢安然;韦棪婷;陈晓璐;杜正彩;侯小涛;邓家刚;
HAO Er-wei;XIE An-ran;WEI Yan-ting;CHEN Xiao-lu;DU Zheng-cai;HOU Xiao-tao;DENG Jia-gang;Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica;Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues;Guangxi Scientific Research Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine;China-ASEAN Joint Laboratory for International Cooperation in Traditional Medicine Research, Guangxi University of Chinese Medicine;Fa

摘要(Abstract):

澜湄五国呈现热带雨林气候特征,疟疾、登革热等重要虫媒传染病是该区域频发的传染病,对区域社会生产和人民生活构成重大威胁。由于使用化学药治疗虫媒性传染病,存在疟原虫的抗药性、登革热病毒尚未发现特效药、化学驱虫剂对环境的污染等诸多问题,单靠化学药治疗已无法解决这一难题。药用植物具有多成分、多靶点及多途径协同发挥的特点,在药物开发中具有极大的潜力。从传统药用植物中寻找治疗登革热、疟疾等虫媒传染病的药物成为关注热点。该文简述虫媒传染病在澜湄五国的流行病学情况,从《中国-东盟传统药物志》的350种药物进行筛选,利用中国知网、维普、PubMed等数据库系统地查阅和整理、分类汇总治疗疟疾、治疗登革热,以及灭蚊、驱蚊作用的传统药用植物,进而对它们的药理作用及机制进行综述,分析其物质基础,为更好地利用传统药用资源,开发安全、有效的防治疟疾、登革热等虫媒性传染病的药物,以及加强中国和澜湄五国进一步的研究合作提供有益的参考。
Arthropod-borne diseases, such as malaria and dengue fever, have frequently beset five countries(Cambodia, Vietnam, Laos, Myanmar, and Thailand) in the tropical rainy Lancang-Mekong region, which pose a huge threat to social production and daily life. As a resort to such diseases, chemical drugs risk the resistance in plasmodium, non-availability for dengue virus, and pollution to the environment. Traditional medicinal plants have the multi-component, multi-target, and multi-pathway characteristics, which are of great potential in drug development. Exploring potential medicinals for arthropod-borne diseases from traditional medicinal plants has become a hot spot. This study summarized the epidemiological background of arthropod-borne diseases in the Lancang-Mekong region and screened effective herbs from the 350 medicinal plants recorded in CHINA-ASEAN Traditional Medicine. Based on CNKI, VIP, and PubMed, the plants for malaria and dengue fever and those for killing and repelling mosquitoes were respectively sorted out. Their pharmacological effects and mechanisms were reviewed and the material basis was analyzed. The result is expected to serve as a reference for efficient utilization of medicinal resources, development of effective and safe drugs for malaria and dengue fever, and the further cooperation between China and the other five countries in the Lancang-Mekong region.

关键词(KeyWords): 中国-东盟传统药用植物;澜湄五国;登革热;疟疾
China-ASEAN traditional medicinal plants;five countries in the Lancang-Mekong region;dengue fever;malaria

Abstract:

Keywords:

基金项目(Foundation): 广西重点研发计划项目(桂科AB20036001,桂科AB20036002);; 广西创新驱动重大专项(桂科AA19254033);; 广西科技基地和人才专项(桂科AD19110155)

作者(Author): 郝二伟;谢安然;韦棪婷;陈晓璐;杜正彩;侯小涛;邓家刚;
HAO Er-wei;XIE An-ran;WEI Yan-ting;CHEN Xiao-lu;DU Zheng-cai;HOU Xiao-tao;DENG Jia-gang;Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica;Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues;Guangxi Scientific Research Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine;China-ASEAN Joint Laboratory for International Cooperation in Traditional Medicine Research, Guangxi University of Chinese Medicine;Fa

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