中国中药杂志

2014, v.39(15) 2956-2959

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参麦注射液对肥厚心肌大鼠左心室乳头肌电活动的影响
Effects of Shenmai injection on afterdepolarization and triggered activities in left ventricular papillary muscle in rat cardiac hypertrophy

焦宏;王晓玲;陈彦静;向丽华;张盛男;
JIAO Hong;WANG Xiao-ling;CHEN Yan-jing;XIANG Li-hua;ZHANG Sheng-nan;Basic Medical College of Hebei North University;The First Affiliated Hospital,Hebei North University;Institute of Basic Theories,China Academy of Chinese Medical Sciences;

摘要(Abstract):

通过观察参麦注射液对肥厚心肌电活动的影响,初步探讨其保护心脏的电生理机制。采用横主动脉弓部分狭窄建立压力超负荷性大鼠心肌肥厚模型,采用玻璃微电极技术记录左心室乳头肌细胞动作电位(AP)及自发的后除极(包括早后除极EAD、迟后除极DAD)。结果显示与假手术组相比,模型组大鼠左心室乳头肌动作电位时程90%复极化时间(APD90)明显延长,参麦注射液组和胺碘酮组无显著性变化;模型组可见明显的EAD和DAD,假手术组未见EAD和DAD的出现,参麦注射液组和胺碘酮组发生率明显降低。结果提示,参麦注射液通过改善肥厚大鼠心肌异常的电生理活动,能够预防其心律失常的发生。
This study is to evaluate the effects of Shenmai injection on the temporal alterations of action potential(AP),early afterdepolarization(EAD) and delayed afterdepolarization(DAD) in papillary muscles.The action potentials were recorded by a glass electrode.APD at 90% repolarization(APD90) was measured,and spontaneous EAD and DAD were observed.The results show APD90 was significantly prolonged in model group compared with sham-operated group,whereas it was remained unchanged in Shenmai injection treatment group and amiodarone group.The spontaneous EADs and DADs were frequently visible in model group.In conclusion,EAD,DAD and trigger activities increase gradually during pathological progression of rat cardiac hypertrophy,and Shenmai injection could improve the action potential change in rat cardiac hypertrophy.

关键词(KeyWords): 参麦注射液;心肌肥厚;后除极;大鼠
Shenmai injection;cardiac hypertrophy;after depolarization;rat

Abstract:

Keywords:

基金项目(Foundation): 河北省科技计划项目(12276104D-39)

作者(Authors): 焦宏;王晓玲;陈彦静;向丽华;张盛男;
JIAO Hong;WANG Xiao-ling;CHEN Yan-jing;XIANG Li-hua;ZHANG Sheng-nan;Basic Medical College of Hebei North University;The First Affiliated Hospital,Hebei North University;Institute of Basic Theories,China Academy of Chinese Medical Sciences;

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