中国中药杂志

2021, v.46(24) 6417-6421

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中药乳香中1个新的西松烷型二萜
A new cembranoid diterpene from Olibanum

陈志超;陈芳有;黄伟明;卞玉婷;罗永明;
CHEN Zhi-chao;CHEN Fang-you;HUANG Wei-ming;BIAN Yu-ting;LUO Yong-ming;School of Pharmacy, Jiangxi University of Chinese Medicine;

摘要(Abstract):

运用MCI、硅胶、ODS和Sephadex LH-20柱色谱以及制备型高效液相等方法,从乳香的醇提物中分离得到了5个化合物,通过波谱数据和文献数据对比分别鉴定为(1S,3R,4S,7R,11S,12R)-1:12,4:7-二环氧西松烷-8(19)-烯-3,11-二醇(1)、boscartin A(2)、(+)-松脂素(3)、(+)-5-hydroxy-3,4-dimethyl-5-pentylfuran-2(5H)-one(4)、acerogenin A(5)。其中化合物1为新化合物,化合物3~5为首次从乳香中分离得到,化合物1的结构通过波谱学分析和X-射线单晶衍射的方法确定。对化合物1和2进行了PC12神经细胞毒性实验,结果显示化合物1和2均是安全性比较好的化合物。
Five compounds were isolated from the alcohol extract of Olibanum by MCI, silica gel, ODS, and Sephadex LH-20 column chromatographies and preparative high-performance liquid chromatography(HPLC). On the basis of spectral data and literature data, the compounds were identified as:(1S,3R,4S,7R,11S,12R)-1:12,4:7-diepoxisonane-8(19)-ene-3,11-diol(1), boscartin A(2),(+)-resinolin(3),(+)-5-hydroxy-3,4-dimethyl-5-pentylfuran-2(5H)-one(4), and acerogenin A(5). Compound 1 is a new compound, and compounds 3-5 were isolated from Olibanum for the first time. The structure of compound 1 was determined by spectroscopic analysis and single-crystal X-ray diffraction. Compounds 1 and 2 were tested for PC12 neurotoxicity, and the results showed that they were both safe compounds.

关键词(KeyWords): 乳香;化学成分;西松烷型二萜;神经细胞毒性
Olibanum;chemical composition;cembranoid diterpene;neurotoxicity

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(82060697);; 江西省“赣鄱英才555工程”项目(5251500119);; 江西中医药大学博士科研启动基金项目(2018BSZR003)

作者(Author): 陈志超;陈芳有;黄伟明;卞玉婷;罗永明;
CHEN Zhi-chao;CHEN Fang-you;HUANG Wei-ming;BIAN Yu-ting;LUO Yong-ming;School of Pharmacy, Jiangxi University of Chinese Medicine;

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