中国中药杂志

2009, v.34(20) 2590-2593

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冬凌草甲素亚微乳的制备及其特性表征
Preparation and characterization of oridonin submicron emulsions

于力;仝新勇;谭燕;
YU Li1,TONG Xinyong1,TAN Yan2(1. Shanghai Hengrui Pharmaceuticals Co. Ltd.,Shanghai 200245,China;2. Scientific and Technical Information Institute,Shanghai Municipal Food and Drug Administration,Shanghai 200233,China)

摘要(Abstract):

目的:制备冬凌草甲素亚微乳,并对其理化性质进行表征。方法:采用高压均质法制备冬凌草甲素亚微乳,并对其粒径、Zeta电位、黏度等性质进行表征。结果:冬凌草甲素亚微乳为白色不透明乳状液体,载药量1g·L-1,平均粒径(138.87±0.60)nm,Zeta电位(47.27±2.31)mV,pH(6.02±0.03),黏度(1.78±0.015)MPa.s。结论:本实验所制得的冬凌草甲素亚微乳理化性质较稳定,工艺简单,可为冬凌草甲素亚微乳制剂的制备提供研究依据。
Objective:To prepare the oridonin submicron emulsion and characterize their properties. Method:High pressure homogenization method was employed to prepare the oridonin submicron emulsion and such properties as size,Zeta potential and viscosity were characterized. Result:The results showed that the submicron emulsions was formed with the drug loading 1 g·L-1,particle size of (138.87±0.60) nm,zeta potential of (47.27±2.31) mV,pH value of (6.02±0.03) and viscosity of (1.78±0.015) MPa·s,respectively. Conclusion:The method is feasible and the submicron emulsions has stable properties. Experiments offer a new formulation of oridonin for clinical application.

关键词(KeyWords): 冬凌草甲素;亚微乳剂;理化性质
oridonin; submicron emulsion; physicochemical properties

Abstract:

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作者(Authors): 于力;仝新勇;谭燕;
YU Li1,TONG Xinyong1,TAN Yan2(1. Shanghai Hengrui Pharmaceuticals Co. Ltd.,Shanghai 200245,China;2. Scientific and Technical Information Institute,Shanghai Municipal Food and Drug Administration,Shanghai 200233,China)

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