中国中药杂志

2012, v.37(03) 373-376

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丹参滴注液中丹参素钠在Beagle犬体内的药代动力学研究
Study on pharmacokinetics of danshensu sodium in danshen dripping solution in Beagles

周玲;张军;谢丽艳;徐洁;稽晶;程建明;居文政;刘子修;刘史佳;谈恒山;
ZHOU Ling1,ZHANG Jun2,XIE Liyan1,XU Jie1,JI Jing1,CHENG Jianming1, JU Wenzheng2,LIU Zixiu1,LIU Shijia2,TAN Hengshan3(1.Nanjing University of Traditional Chinese Medicine,Nanjing 210046,China; 2.Department of Clinical Pharmacology,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210046,China; 3.General Hospital of Armed Forces of Nanjing,Nanjing 210002,China)

摘要(Abstract):

目的:探讨丹参滴注液中丹参素钠在Beagle犬体内的药代动力学。方法:健康Beagle犬禁食12 h后,静脉滴注丹参滴注液10 mL.kg-1,血浆样品用乙酸乙酯提取,采用HPLC测定不同时间血药浓度。结果:丹参素钠在0.225~18.000mg.L-1线性关系良好,最低检测限为0.113 mg.L-1,Beagle犬静脉滴注丹参滴注液后的药代动力学参数:tmax为30 min,Cmax为(9.574 2±2.371 5)mg.L-1,t1/2为(19.23±2.97)min,CL为(0.012 7±0.003 0)L.min-1.kg-1,AUC0-tn为(474.954±95.483)mg.min.L-1,AUC0-∞为(482.494±95.353)mg.min.L-1。结论:所建立血药浓度检测方法简便、稳定、可靠,丹参素钠在Beagle犬体内呈单室模型。
Objective:To detect pharmacokinetics of Danshensu Sodium in Danshen dripping solution in Beagles.Method: Danshen dripping solution was dripped intravenously into healthy Beagles at a dose of 10 mL·kg-1.Their plasma samples were extracted with acetic ether,the blood concentrations were determined by HPLC method.Result: Danshensu Sodium showed a good linear relationship within the range of 0.225-18.000 mg·L-1,with the lowest detectable limit of 0.113 mg·L-1.Its pharmacokinetic parameters were as follows: tmax was 30 min,Cmax was(9.574 2±2.371 5) mg·L-1,t1/2 was(19.23±2.97) min,CL was(0.012 7±0.003 0) L·min-1·kg-1,AUC0-tn was(474.954±95.483) mg·min·L-1 and AUC0-∞ was(482.494±95.353) mg·min·L-1.Conclusion: The accurate,stable and reliable blood concentration method shows a one-compartment mode of Danshensu Sodium in Beagles.

关键词(KeyWords): 丹参滴注液;HPLC;丹参素钠;药代动力学
Danshen dripping solution;HPLC;Danshensu sodium;pharmacokinetics

Abstract:

Keywords:

基金项目(Foundation): 江苏省高校优势学科建议工程项目;; 江苏省中医药领军人才项目(LJ200906)

作者(Authors): 周玲;张军;谢丽艳;徐洁;稽晶;程建明;居文政;刘子修;刘史佳;谈恒山;
ZHOU Ling1,ZHANG Jun2,XIE Liyan1,XU Jie1,JI Jing1,CHENG Jianming1, JU Wenzheng2,LIU Zixiu1,LIU Shijia2,TAN Hengshan3(1.Nanjing University of Traditional Chinese Medicine,Nanjing 210046,China; 2.Department of Clinical Pharmacology,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210046,China; 3.General Hospital of Armed Forces of Nanjing,Nanjing 210002,China)

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