中国中药杂志

2009, v.34(23) 3105-3109

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融斑通脉颗粒对鹌鹑动脉粥样硬化治疗作用的实验研究
Herapeutic effects of Rongban Tongmai granules on atherosclerosis in quails

林成仁;王敏;马雪瑛;刘建勋;
LIN Chengren,WANG Min,MA Xueying,LIU Jianxun(Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)

摘要(Abstract):

目的:观察融斑通脉颗粒对鹌鹑动脉粥样硬化(AS)的治疗作用。方法:将鹌鹑分为正常对照组和高脂组,高脂喂养至12周后,正常组随机解剖3只,高脂组随机解剖8只,经病理学检查确定AS形成后,将高脂组分为模型对照组,舒降之0.004 g.kg-1剂量组,融斑通脉颗粒3,6,12 g.kg-1剂量组;换喂普通饲料,同时灌胃给药,于实验前、给药前、给药4周、给药8周、给药12周测定血液中血脂(TC,TG,HDL-C,LDL-C)水平,实验结束时,取主动脉、左右头臂动脉及心脏进行病理学检查,并测定肝脏组织脂质(TC,TG)含量、MDA含量及SOD活性。结果:融斑通脉颗粒明显加速AS模型鹌鹑血清TC,LDL-C,VLDL-C水平及TC/HDL-C趋于正常,对肝脏TG和MDA含量有明显降低作用,明显减少斑块面积和厚度。结论:融斑通脉颗粒具有降低血脂、减轻脂质过氧化的作用,同时在一定程度上抑制AS病变的发展,并促使其消退。
Objective:To explore the therapeutic effects of Rongban Tongmai granules(RBTM) on the atherosclerosis(AS) in quails.Method: Quails were divided into normal control group and high-fat diet group.Twelve weeks after feeding,3 quails from normal control group and 8 quails from high-fat diet group were anatomized and confirmed by pathological examination that AS has formed,then the high-fat diet group was randomly divided into 5 subgroups: Model,shujiangzhi 0.004 g·kg-1 and RBTM(3,6,12 g·kg-1).High fat fodder was stoped.Meanwhile,normal fodder was fed and drugs were administrated by gavage.The levels of the TC,TG,HDL-C,LDL-C in serum were determined at the time points below: Pre-experiment,per-drug administration,4 weeks after drug administration,8 weeks after drug administration,12 weeks after drug administration.After experiment,pathological examination was performed on aorta,bilateral brachiocephalic artery and heart.Meanwhile,the levels of TC,TG and MDA as well as the activity of SOD in liver tissue were determined.Result: The levels of TC,TG,LDL-C,VLDL-C and TC/HDL-C ratio in serum of AS quails were significantly decreased,the levels of TG and MDA in liver were decreased,the thickness and area of the plaque were significantly decreased.Conclusion: RBTM might have effects of modulating blood lipid and improving lipid peroxidation,and also contribute to inhibit the development of AS and accelerate AS regression.

关键词(KeyWords): 融斑通脉颗粒;动脉粥样硬化;血脂;消退
Rongban Tongmai granules(RBTM);atherosclerosis;blood lipid;regression

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金重点项目(30630073)

作者(Authors): 林成仁;王敏;马雪瑛;刘建勋;
LIN Chengren,WANG Min,MA Xueying,LIU Jianxun(Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)

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