中国中药杂志

2017, v.42(02) 264-273

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基于多元功效成分的当归药材产地现代干燥加工方法研究
Modern drying processing method for Angelicae Sinensis Radix based on multi-bioactive constituents

朱邵晴;郭盛;钱大玮;沙秀秀;鲁学军;严辉;朱振华;蒋颖;段金廒;
ZHU Shao-qing;GUO Sheng;QIAN Da-wei;SHA Xiu-xiu;LU Xue-jun;YAN Hui;ZHU Zhen-hua;JIANG Ying;DUAN Jin-ao;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine,Nanjing University of Chinese Medicine;

摘要(Abstract):

为建立当归药材产地现代干燥加工方法体系,该研究以3种酚酸(酯)类、6种苯酞类及多糖类化学成分的组成及含量为评价指标,利用主成分分析法,结合干燥后样品外观性状等指标,对经不同干燥加工方法所得当归药材样品品质进行综合评价,并在此基础上对其工艺参数进行了优化。结果显示,经控温控湿、中短波红外及微波真空干燥法加工后的当归药材所含绿原酸、阿魏酸显著高于新鲜样品及产地传统干燥方法加工样品;多元统计方法分析结果显示,采用控温控湿干燥法加工样品,其整体化学特征与产地传统干燥方法加工样品较为近似,可作为当归药材产地现代干燥加工的适宜方法。以产地传统干燥加工方法所得当归药材样品为参照,采用正交试验设计法对当归药材控温控湿干燥工艺参数进行了优化,综合考虑能耗、干燥时间等其他参数,最终确定当归药材产地现代干燥加工适宜工艺为:采用控温控湿干燥法,第一阶段干燥温度40~45℃,相对湿度25%以下,干燥目标水分50%,缓苏时间12~24 h,第二阶段干燥温度60~65℃,相对湿度20%以下,风速35~40 Hz。该研究为当归药材产地现代干燥加工方法的选择以及工艺参数优化提供了支撑,也为根及根茎类药材产地加工共性技术的形成提供了有益探索和实践。
To provide a scientific basis for the selection and optimization of the modern drying processing method for Angelicae Sinensis Radix( ASR). Three phenolic acids( esters),6 phthalides were determined by using UPLC-PDA while polysaccharides were determined by UV-Vis spectrophotometry. Then the effects of drying methods on the inner qualities of ASR were evaluated through principle components analysis( PCA) combined with the appearance properties after drying. Results showed that the contents of chlorogenic acid and ferulic acid in samples obtained with controlled temperature and humidity drying( CTHD),medium and shortwave infrared drying( MSID) and microwave vacuum drying(MVD) methods were significantly higher than those with primary drying processing(PDP) method and the fresh samples. Multivariate statistical analysis showed that samples processed with CTHD had more similar general chemical properties with those processed with PDP,suggesting that CTHD was appropriate for the modern primary drying processing of ASR. With samples processed with traditional PDP method as reference,the CTHD method was further optimized in the processing parameters for ASR by orthogonal experiment design. Considering the consumption of drying power and time and other parameters,the modern drying parameters for the primary drying processing of ASR were finally optimized as follows: controlled temperature and humidity drying at 40-45℃,relative humidity below 25% and target moisture content about 50% in the first stage of drying process,tempering for 12-24 h,and then drying under the conditions of temperature at 50-60 ℃,relative humidity below 20% and fan frequency at 30-40 Hz in the second stage. The study provided the scientific evidence for the selection of appropriate drying method and suitable parameters for the modern primary drying processing of ASR,as well as the beneficial exploration and practice on the formation of technical standard of primary drying processing for roots and rhizomes types herbal medicines.

关键词(KeyWords): 当归;干燥方法;加工工艺;酚酸类;苯酞类;多糖类;综合评价
Angelica sinensis;drying method;process optimization;phenolic acids;phthalides;polysaccharides;comprehensive assessment

Abstract:

Keywords:

基金项目(Foundation): 公益性行业科研专项(201407005);; 江苏高校优势学科建设工程项目(ysxk-2014);; 国家自然科学基金青年基金项目(81202862);; 中央本级重大增减支项目(2060302-1601-10);; 国家中药标准化项目(ZYBZH-C-JS-34)

作者(Author): 朱邵晴;郭盛;钱大玮;沙秀秀;鲁学军;严辉;朱振华;蒋颖;段金廒;
ZHU Shao-qing;GUO Sheng;QIAN Da-wei;SHA Xiu-xiu;LU Xue-jun;YAN Hui;ZHU Zhen-hua;JIANG Ying;DUAN Jin-ao;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine,Nanjing University of Chinese Medicine;

Email:

DOI: 10.19540/j.cnki.cjcmm.20170103.026

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