中国中药杂志

2013, v.38(21) 3763-3767

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醒脑静口服制剂中冰片在脑缺血及假手术大鼠脑组织和血浆中药物动力学研究
Comparative pharmacokinetic studies of borneol in brain and plasma of stroke or sham-operated rats after administration of Xingnaojing

徐攀;杜守颖;黎迎;陆洋;白洁;郭青丽;
XU Pan;DU Shou-ying;LI Ying;LU Yang;BAI Jie;GUO Qing-li;Beijing University of Chinese Medicine;

摘要(Abstract):

为了研究醒脑静中冰片在脑中风病理状态脑和血中的药动学特征,并评价脑中风对冰片透过血脑屏障能力的影响。该实验采用大脑中动脉线栓再灌注法建立并选取脑中风模型大鼠,并设立假手术组,灌胃给予醒脑静混悬液,不同时间点采血后进行GC测定,以Kinetica软件拟合,计算相关药动学参数。结果表明在脑中风状态下的脑、血的C max为(1.82±0.825),(1.35±0.43)mg·L-1,AUC0-t为(123.39±55.82),(87.91±39.81)mg·L-1·min,T e(脑/血药物比)(71.3±3.24)%,大于假手术组的各个参数。从结果中可以看出脑中风的发生能够促进醒脑静中冰片透过血脑屏障,增加冰片的入脑量,为冰片的合理使用以及醒脑静口服制剂的研究提供了参考。
In order to research the pharmacokinetic characteristic of borneol in plasma and brain of stroke rats given XNJ and investigate the influence of stroke on the borneol passing through the blood-brain barrier,this study established the GC to determine the borneol in brain and blood,and made the stroke mode rats by middle carotid artery occlusion( MCAO) and set sham-operated group. After oral administration of Xingnaojing( XNJ) suspension,their blood and brain were collected at different time and detected by GC. The data was analysed by Kinetica. Results showed that in stroke group,the C max and AUC 0-t of brain and plasma are(1. 82 ± 0. 825),(1. 35 ±0. 43) mg·L- 1and(123. 39 ±55. 82),(87. 91 ±39. 81) mg·L- 1·min,T e(brain/blood drug ratio) was 70. 93%; those pharmacokinetic values were larger than in sham-operated group. We can conclude that the pathological state of stroke can increase the amount of borneol permeating into brain.

关键词(KeyWords): 冰片;醒脑静;脑组织;药代动力学
borneol;Xingnaojing;brain;pharmacokinetics

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基金项目(Foundation): 国家自然科学基金面上项目(81073057);; 北京中医药大学复方中药制药研究创新团队项目(2011-CXTD-13);; 北京中医药大学自主课题项目(2011-JYBZZ-JS048)

作者(Author): 徐攀;杜守颖;黎迎;陆洋;白洁;郭青丽;
XU Pan;DU Shou-ying;LI Ying;LU Yang;BAI Jie;GUO Qing-li;Beijing University of Chinese Medicine;

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