中国中药杂志

2014, v.39(21) 4123-4126

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桂枝茯苓胶囊及药材中多元素ICP-MS测定方法的建立
Analysis methodology of multi element in four herbs of Guizhi Fuling capsules

王金玲;李家春;胡军华;黄文哲;王振中;萧伟;
WANG Jin-ling;LI Jia-chun;HU Jun-hua;HUANG Wen-zhe;WANG Zhen-zhong;XIAO Wei;Jangsu Kanion Pharmaceutical Co. Ltd.;State Key Laberatory of New-tech for Chinese Medicine Pharmaceutical Process;

摘要(Abstract):

该文采用微波消解法对桂枝茯苓胶囊及5味药材(桂枝、茯苓、白芍、桃仁、牡丹皮)进行消解、电感耦合等离子体质谱仪建立了铅(Pb)、铜(Cu)、砷(As)、镉(Cd)、汞(Hg)、镁(Mg)、锰(Mn)、镍(Ni)、铊(Tl)等多元素同时检测的方法,以内标法进行定量以改善基体效应和干扰。实验结果表明各元素的线性关系良好,相关系数R2≥0.999 3;方法检出限为0.016~4.593μg·L-1,实验重复性良好;加样回收率在75.84%~118.9%。该方法灵敏度高,专属性好,为控制桂枝茯苓胶囊中有害元素提供依据,也为监控及制订中药材中有害元素的限量提供参考。
This paper was focused on establishing a ICP-MS method with microwave digestion for simultaneous determination of lead,copper,arsenic,cadmium,mercury,magnesium,manganese,nickel,thallium in cassia tuckahoe capsule and its five raw herbal materials. Internal standard method was adopted to reduce matrix effect and other interference effects. The method established was shown to be simple with high sensitivity,strong specificity and good reproducibility. linear relationship is good as R2≥0. 999 3 while the average recovery was among 75. 84%-118. 9%. The detection limit was 0. 016-4. 593 μg·L- 1. Data in this paper provided the basis for control of deleterious element in Guizhi Fuling capsules,and further more it was with referencing values for control of deleterious element in other crude drug.

关键词(KeyWords): 桂枝茯苓胶囊;电感耦合等离子质谱;微波消解;元素分析
Guizhi Fuling capsules;inductively coupled plasma mass spectrometer(ICP-MS);microwaves digest;element analysis

Abstract:

Keywords:

基金项目(Foundation): 国家“重大新药创制”科技重大专项(2013ZX09402203)

作者(Author): 王金玲;李家春;胡军华;黄文哲;王振中;萧伟;
WANG Jin-ling;LI Jia-chun;HU Jun-hua;HUANG Wen-zhe;WANG Zhen-zhong;XIAO Wei;Jangsu Kanion Pharmaceutical Co. Ltd.;State Key Laberatory of New-tech for Chinese Medicine Pharmaceutical Process;

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