斑马鱼——一种可用于中药药效和毒性筛选的鱼类模型Zebrafish——Useful model for pharmacodynamics and toxicity screening of traditional Chinese medicine
梁爱华;
摘要(Abstract):
斑马鱼是一种用于生长发育和遗传研究的重要模式生物,过去10余年来,被广泛应用于环境毒物的监测,已经被用于环境中许多化学物质如有害重金属、农药以及卤代芳香烃化合物等致癌物的累积效应和毒性研究。近年来,该模型越来越多地应用于药物筛选和毒理学研究。斑马鱼具有活体、高通量的优点,尤其适用于中药混合物的药效和毒性筛选,在中药新药研究领域具有较广的应用前景。
关键词(KeyWords): 斑马鱼;新药筛选;药效学;毒性
基金项目(Foundation): 国家科技部重大专项项目(2009ZX09301-005-08)
作者(Author): 梁爱华;
Email:
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