中国中药杂志

2013, v.38(07) 1018-1020

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大洋纵列海鞘中的嘌呤和咔啉生物碱成分研究
Purine and carboline alkaloids from ascidian Symplegma oceania

赵树明;陆亚男;田晓清;杨桥;于慧娟;樊成奇;
ZHAO Shu-ming1,2,LU Ya-nan1,TIAN Xiao-qing1,YANG Qiao1,YU Hui-juan1,FAN Cheng-qi1*(1.Key Laboratory of East China Sea & Oceanic Fishery Resources Exploitation and Utilization,Ministry of Agriculture,East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Shanghai 200090,China;2.Shanghai Ocean University,Shanghai 201306,China)

摘要(Abstract):

从大洋纵列海鞘Symplegma oceania的甲醇提取部位中分离鉴定了5个嘌呤和咔啉生物碱成分,采用包括HPLC在内的多种色谱方法进行分离纯化,应用多种波谱学方法,主要是MS,1H-NMR和13C-NMR,结合文献对照确定上述化合物的结构为6-甲氧基-7-甲基-8-氧鸟嘌呤(1),2-甲基亚氨基-3-甲基-6-甲基氨基-9-氢-嘌呤(2),1,2,3,4-四氢-β-咔啉(3),1-甲基四氢-β-咔啉(4)和1,2,3,4-四氢-β-咔啉-3-羧酸(5),其中化合物2~5均为首次从Symplegma属海鞘中获得,嘌呤、咔啉类是该种海鞘中生物碱成分的主要类型。
Five purine and carboline alkaloids were isolated from the methanol extract of the ascidian Symplegma oceania.Classic chromatographies including preparative HPLC were used for isolation and purification of the compounds.The structures were established as 6-methoxy-7-methyl-8-oxoguanine(1),2-methylimino-3-methyl-6-methylamino-9H-purine(2),1,2,3,4-tetrahydro-βcarboline(3),1,2,3,4-tetrahydro-1-methyl-β-carboline(4) and 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid(5) by comparison the spectroscopic data(MS,1H,13C-NMR) with those reported in the literatures.Compounds 2-5 were reported from the the genus Symplegma for the first time.The purine and carboline were the major alkaloid types of S.oceania.

关键词(KeyWords): 海鞘科;大洋纵列海鞘;嘌呤;咔啉
Styelidae;Symplegma oceania;purine;carboline

Abstract:

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基金项目(Foundation): 中央级公益性科研院所基本科研业务费专项(2007M16);; 上海海洋大学研究生科研基金项目(A-2500-11-0065)

作者(Author): 赵树明;陆亚男;田晓清;杨桥;于慧娟;樊成奇;
ZHAO Shu-ming1,2,LU Ya-nan1,TIAN Xiao-qing1,YANG Qiao1,YU Hui-juan1,FAN Cheng-qi1*(1.Key Laboratory of East China Sea & Oceanic Fishery Resources Exploitation and Utilization,Ministry of Agriculture,East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Shanghai 200090,China;2.Shanghai Ocean University,Shanghai 201306,China)

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