中国中药杂志

2012, v.37(21) 3233-3235

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不同粒径连翘粉体中连翘苷体外溶出研究
In vitro dissolution of forsythin in Forsythia suspensa powder of different particle diameter

刘新义;张水寒;李健和;向大雄;易利丹;叶祖光;
LIU Xin-yi1,ZHANG Shui-han2,LI Jian-he1,XIANG Da-xiong1,YI Li-dan1,YE Zu-guang3(1.Key Research Laboratory for Development of New Drugs,The Second Xiangya Hospital of Central South University, Changsha 410013,China;2.Hunan Academy of Traditional Chinese Medicine,Changsha 410006,China; 3.China Academy of Chinese Medical Sciences,Beijing 100700,China)

摘要(Abstract):

目的:考察不同粒径连翘粉体中连翘苷的体外溶出规律,以指导粉碎加工技术。方法:采用HPLC测定连翘粗粉、细粉、超微粉中连翘苷的溶出量和溶出速率,并以数学模型拟合溶出曲线。结果:连翘粗粉、细粉、超微粉溶出曲线基本符合威布尔分布,其中T50分别为11.8,10.5,6.8 min,Q45分别为78.22%,81.91%,90.76%。结论:连翘药材经超微化后可明显提高连翘苷的溶出量和溶出速率。
Objective: To examine the in vitro dissolution of forsythin in Forsythia suspensa powder of different particle diameter,in order to give guidance to the grinding process.Method: HPLC was used to determine the in vitro dissolution quantity and dissolution velocity of forsythin coarse powder,fine powder and ultramicroscopic powder.Result: The dissolution curves of Forsythia suspensa coarse powder,fine powder and ultramicroscopic powder were basically inconformity to Weibull distribution.Specifically,T50 was 11.8,10.5 and 6.8 min,respectively,and Q45 was 78.22%,81.91% and 90.76%,respectively.Conclusion: The superfine milling process can significantly increase the dissolution quantity and dissolution velocity of forsythin.

关键词(KeyWords): 连翘;连翘苷;溶出量;溶出速率;威布尔分布
Forsythia suspensa;forsythin;dissolution quantity;dissolution velocity;Weibull distribution

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基金项目(Foundation): 湖南省科技厅重点项目(06FJ2005)

作者(Author): 刘新义;张水寒;李健和;向大雄;易利丹;叶祖光;
LIU Xin-yi1,ZHANG Shui-han2,LI Jian-he1,XIANG Da-xiong1,YI Li-dan1,YE Zu-guang3(1.Key Research Laboratory for Development of New Drugs,The Second Xiangya Hospital of Central South University, Changsha 410013,China;2.Hunan Academy of Traditional Chinese Medicine,Changsha 410006,China; 3.China Academy of Chinese Medical Sciences,Beijing 100700,China)

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