中国中药杂志

2016, v.41(08) 1380-1382

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999感冒灵浓缩过程蒙花苷热降解规律研究
Modeling of thermal degradation of linarin during concentration process

邓海欣;潘红烨;陈周全;张跃飞;王龙虎;
DENG Hai-xin;PAN Hong-ye;CHEN Zhou-quan;ZHANG Yue-fei;Wang Long-hu;Colleage of Pharmaceutical Sciences Zhejiang University;China Resources Sanjiu Medical & Pharmaceutical Co.,Ltd.;

摘要(Abstract):

蒙花苷为999感冒灵颗粒处方中野菊花代表性黄酮类成分,是感冒灵颗粒剂重要的中药有效成分。蒙花苷属于热敏性化合物,易受热降解,其热稳定性差是影响感冒灵质量控制的难题之一。该研究以成分保留率为评价指标,考察了溶液浓缩温度、真空度和浓缩时间等因素的影响作用,探讨了浓缩过程蒙花苷受热降解的变化规律。研究结果表明,蒙花苷的热降解变化符合一级反应特征,浓缩过程只要控制温度和时间,可有效地避免蒙花苷损失。该研究成果对于感冒灵颗粒剂生产工艺有指导作用,中药水提液的浓缩温度宜控制在85℃以下,浓缩时间不超过9.3 h,以保证蒙花苷损失率不超过10%;如果浓缩温度在85℃以上,要控制同样的蒙花苷损失率,浓缩时间则不能超过5 h,以保证浓缩液中蒙花苷损失量小于10%。
Ganmaoling granule,with annual sale of over one billion yuan,is the first brand of domestic cold medicine sales. As the only traditonal Chinese medicine( TCM) quality control indicator of Ganmaoling granule,linarin is thermally unstable. Its content will be changed significantly during the production process,which would then affect the quality of the finished product. In this paper,the law of degradation of linarin was investigated. The experimental results showed that degradation reaction of linarin belongs to the first reaction characteristics. The effective methods to reduce the loss of linarin would be realized fortunately by strictly controlling the heating temperature or shortening the heating time.

关键词(KeyWords): 蒙花苷;浓缩过程;热稳定;感冒灵
linarin;concentration process;thermal stability;Ganmaoling granules

Abstract:

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基金项目(Foundation): 国家”重大新药创制”科技重大专项(2012ZX09201201)

作者(Author): 邓海欣;潘红烨;陈周全;张跃飞;王龙虎;
DENG Hai-xin;PAN Hong-ye;CHEN Zhou-quan;ZHANG Yue-fei;Wang Long-hu;Colleage of Pharmaceutical Sciences Zhejiang University;China Resources Sanjiu Medical & Pharmaceutical Co.,Ltd.;

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