中国中药杂志

2014, v.39(10) 1933-1936

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芩百清肺浓缩丸药物配伍对黄芩苷吸收的药动学比较
Pharmacokinetic comparison of baicalin absorption medicine Qinbai Qingfei concentrated pellets drug compatibility

李海龙;冯文成;姚琳;孙妍;宋亚娟;胡昊;王伟明;
LI Hai-long;FENG Wen-cheng;YAO Lin;SUN Yan;SONG Ya-juan;HU Hao;WANG Wei-ming;Heilongjiang Traditional Medical Academy of Sciences;

摘要(Abstract):

将芩百清肺浓缩丸按中药方剂理论拆方并分组,通过给大鼠灌胃各受试药物组,比较各组黄芩苷药动学参数的变化,阐明芩百组方的合理性及臣药在组方中的重要作用。对大鼠进行分组,分别灌胃君药组(黄芩粗提物,主要为黄芩苷)、与君药组黄芩苷含量相等的臣药组及芩百组(全方组),在28 h内于不同时间点采集大鼠血浆,应用HPLC测定大鼠血浆中的黄芩苷的药时曲线,用3P97实用药动学计算程序对所得数据进行处理。通过对数据分析得出,芩百全方组大鼠血浆中黄芩苷的Cmax是君药组的4倍,AUC是君药组的6倍;芩百全方组大鼠血浆中黄芩苷含量最高,臣药组大鼠血浆中黄芩苷含量不及全方组,但明显高于君药组。通过以上药动学结果得知,芩百能明显增加黄芩苷的Cmax和AUC,芩百中的其他中药成分促进了黄芩苷在体内的吸收,表明芩百复方配伍的合理;臣药对黄芩苷的体内吸收有促进作用。
The Qinbai Qingfei concentrated pellets by traditional Chinese medicine theoryand party and group,the rats were given the drugs group,comparison of pharmacokinetics parameters changes of baicalin,discusses the rationality of Qinbai prescription.The rats were gavaged monarch drug group( Huang Qincu extract,mainly forbaicalin),and official medicine group,adjuvant group,medicine group and Qinbai group(Quan Fangzu) the content of baicalin equal as the monarch drug group,in the 28 h collection in rat plasma at different time point,application of HPLC determination of baicalin glycosides in rat plasmaconcentration time curve,with3P97 practical pharmacokinetics program to process the data.Based on the data analysis,baicalin in rat plasma of Qinbai group Cmaxis4 times as big as monarch druggroup,AUC is 6 times as big as monarch drug group; the content of baicalin in plasma of rats the highest is Qinbai group,the minister drug group,adjuvant group,medicine group of baicalin in rat plasma content of less than the Qinbai group,but was significantly higher than that of monarch drug group; the medicine group is slightly higher than that adjuvant the content of baicalin in plasma of rats.The pharmacokinetic results show that the measured plasma concentration in rats that Qinbai can significantly increase Cmaxand AUC of baicalin,other components of qinbai can promoted the baicalin absorption in vivo.It showed that the reasonable of Qinbai compound compatibility.The minister drug can promote the absorption of baicalin in vivo.

关键词(KeyWords): 黄芩苷;配伍;药代动力学;芩百清肺浓缩丸
baicalin;compatibility;pharmacokinetics;Qinbai Qingfei concentrated pills

Abstract:

Keywords:

基金项目(Foundation): 国家“重大新药创制”科技重大专项(2010ZX09101-104);; 黑龙江省中医药科研项目(ZHY12-Z128);; 黑龙江省杰出青年基金项目(JC200813)

作者(Author): 李海龙;冯文成;姚琳;孙妍;宋亚娟;胡昊;王伟明;
LI Hai-long;FENG Wen-cheng;YAO Lin;SUN Yan;SONG Ya-juan;HU Hao;WANG Wei-ming;Heilongjiang Traditional Medical Academy of Sciences;

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