中国中药杂志

2021, v.46(02) 312-319

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生物碱类天然产物抗乳腺肿瘤机制研究进展
Progress of studies on anti-breast tumor mechanism of alkaloids

张攀;张宜凡;陈群力;杜望春;姚虹;赵梅;
ZHANG Pan;ZHANG Yi-fan;CHEN Qun-li;DU Wang-chun;YAO Hong;ZHAO Mei;Graduate School, Shanghai University of Chinese Medicine;Department of Pharmacy, Shanghai University of Medicine & Health Sciences;

摘要(Abstract):

乳腺肿瘤已成为发病率最高的恶性肿瘤之一,严重威胁人类尤其是女性健康。化疗是抗乳腺肿瘤的重要治疗方法,其通过单独使用或与手术、放射治疗结合使用,几乎可用于乳腺肿瘤治疗的各个阶段。生物碱类化合物是自然界普遍存在的一类天然产物,是多种药用植物的重要活性成分。大量的研究表明,生物碱类化合物可通过抑制增殖、转移和血管生成、抗有丝分裂、促进细胞凋亡和自噬、触发细胞周期阻滞等多种途径发挥抗乳腺肿瘤作用。生物碱类化合物广泛的抗乳腺肿瘤作用使其成为重要的抗乳腺肿瘤候选药物来源。该文就生物碱类天然产物抗乳腺肿瘤机制展开综述。
Breast tumor has become one of the malignant tumors with the highest incidence, and is a serious threat to human health, especially to women. Chemotherapy is an important anti-breast tumor therapy, which can be used in almost every stage of breast tumor therapy alone or in the combination with surgery and radiation therapy. Alkaloids are a kind of ubiquitous natural products, and important active components of various medicinal plants. A large number of studies have shown that alkaloids could exert an anti-breast tumor effect by inhibiting proliferation, metastasis and angiogenesis, resisting mitosis, promoting apoptosis and autophagy, and triggering cell cycle arrest. The extensive anti-breast tumor effect makes alkaloids an important candidate drug source. This paper reviews the anti-breast tumor mechanism of natural products of alkaloids.

关键词(KeyWords): 生物碱;乳腺肿瘤;抗肿瘤机制
alkaloids;breast tumor;anti-tumor mechanism

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金青年基金项目(81602729)

作者(Authors): 张攀;张宜凡;陈群力;杜望春;姚虹;赵梅;
ZHANG Pan;ZHANG Yi-fan;CHEN Qun-li;DU Wang-chun;YAO Hong;ZHAO Mei;Graduate School, Shanghai University of Chinese Medicine;Department of Pharmacy, Shanghai University of Medicine & Health Sciences;

DOI: 10.19540/j.cnki.cjcmm.20201015.601

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