中国中药杂志

1998, (04)

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生脉散复方化学动态变化与药效关系的研究——生脉散复方化学的研究(Ⅰ)
A Research on Chemical Dynamic Changes and Drug Efficacy of SMS Compound Prescription Chemical Researches on SMS Prescription

夏云,李志明,朱丹妮,严永清
Xia Yun,Li Zhiming,Zhu Danni and Yan Yongqing (Department of Chinese Medicinal Prescription,China Pharmaceutical University,Nanjing 210038)

摘要(Abstract):

为探讨生脉散全方独特疗效作用的物质基础,对其煎煮后的化学成分进行了研究。从生脉散合煎剂中分离得到一个复方产生的新成分,经UV,IR,MS及NMR谱鉴定为5羟甲基2糠醛。研究表明,复方独特疗效有其独特的物质基础,与单味药及其简单加和在化学成分上有本质区别。从而阐明了中药配伍应用的合理性和科学性,并为制定复方制剂的质量检测提供了依据
To clarify the material base of the distinct curative effect of Shengmaisan (SMS) compound prescription,a study was made on the dynamics of chemical constituents in the decoction prepared according to the compound prescription.From the decoction a new compound was isolated and identified by UV,IR,MS and NMR as 5hydroxymethy2furaldehyde (5HMF).The study suggests that the distinct curative effect of SMS compound prescription hinges on a material base which is different chemically from that in the other three single drugs used separately,thus presenting scientific criteria for rational compatibility and quality check in making preparations on compound prescriptions.

关键词(KeyWords): 生脉散,5-羟甲基-2-糠醛,复方化学
Shengmaisan;5-hydroxymethyl-2-furaldehyde;prescription chemistry

Abstract:

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基金项目(Foundation): 国家自然科学基金

作者(Author): 夏云,李志明,朱丹妮,严永清
Xia Yun,Li Zhiming,Zhu Danni and Yan Yongqing (Department of Chinese Medicinal Prescription,China Pharmaceutical University,Nanjing 210038)

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