中国中药杂志

2011, v.36(02) 166-168

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单麻叶千里光中肝毒吡咯里西啶生物碱的分离与鉴定
Pyrrolizidine alkaloids of Senecio cannabifolius var. integrilifolius

马鸿雁;杨莉;王长虹;王峥涛;
MA Hongyan1,2,YANG Li1,WANG Changhong1,WANG Zhengtao1(1.Key Laboratory for Standardization of Chinese Medicines and State Administration of Traditional Chinese Medicine,Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines,ShanghaiKey Laboratory for Compound Chinese Medicines,Institute of Chinese Materia Medica ofShanghai University of Traditional Chinese Medicine,Shanghai 201203,China;2.Guangdong Pharmaceutical University,Guangzhou 510000,China)

摘要(Abstract):

目的:研究菊科千里光属植物单麻叶千里光Senecio cannabifoliusvar.integrilifolius的肝毒性吡咯里西啶生物碱。方法:运用多种色谱方法进行分离纯化,应用现代波谱学分析方法进行结构鉴定。结果:从单麻叶千里光的总碱部位中分离得到4个吡咯里西啶生物碱,分别鉴定为:jacobine(1),jacoline(2),jaconine(3),senecicannabine(4)。结论:化合物1~4均为首次从该植物中分离得到。
Objective: To study the pyrrolizidine alkaloids of Senecio cannabifolius var.integrilifolius.Method: Various chromatographic methods were used for the isolation and purification of chemical constitutents of the plant and their structures were elucidated on the basis of spectral analysis.Result: Four compounds were determinated as jacobine(1),jacoline(2),jaconine(3),senecicannabine(4).Conclusion: All compounds were isolated from this plant for the first time.

关键词(KeyWords): 单麻叶千里光;化学成分;吡咯里西啶生物碱
Senecio cannabifolius var.integrilifolius;chemical constituents;pyrrolizidine alkaloids.

Abstract:

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基金项目(Foundation): 国家自然科学基金项目(30701104);; 国家重点基础研究发展(973)计划项目(2006CB504704)

作者(Author): 马鸿雁;杨莉;王长虹;王峥涛;
MA Hongyan1,2,YANG Li1,WANG Changhong1,WANG Zhengtao1(1.Key Laboratory for Standardization of Chinese Medicines and State Administration of Traditional Chinese Medicine,Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines,ShanghaiKey Laboratory for Compound Chinese Medicines,Institute of Chinese Materia Medica ofShanghai University of Traditional Chinese Medicine,Shanghai 201203,China;2.Guangdong Pharmaceutical University,Guangzhou 510000,China)

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