中国中药杂志

2018, v.43(11) 2269-2273

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中药生物药剂学分类系统中多成分环境下小檗碱的特性溶出速率研究
Impacts of multicomponent environment on intrinsic dissolution rate of berberine in biopharmaceutics classification system of Chinese materia medica

尹秀文;王子禹;潘孟;张鑫;王静;李彦萍;董玲;
YIN Xiu-wen;WANG Zi-yu;PAN Meng;ZHANG Xin;WANG Jing;LI Yan-ping;DONG Ling;Beijing University of Chinese Medicine;

摘要(Abstract):

该研究就中药生物药剂学分类系统(biopharmaceutics classification system of Chinese materia medica,CMMBCS)中的特性溶出速率问题,利用旋转盘系统考察人工制造的多成分环境对特性溶出速率的影响,并利用所获数据进行分析总结相关规律。采用递进式设计,分别研究了单一成分(葛根素、黄芩苷和甘草酸)、2成分(葛根素+黄芩苷,葛根素+甘草酸,黄芩苷+甘草酸)和3成分(葛根素+黄芩苷+甘草酸)环境对小檗碱特性溶出速率的影响趋势,为多成分环境下中药成分的吸收相关研究奠定基础。
To illustrate the intrinsic dissolution rate( IDR) involved in biopharmaceutics classification system of Chinese materia medica( CMMBCS),investigate the effect of artificial multicomponent environment on IDR of berberine,by using a non-disintegrating disk,and summarize related rules by using the obtained data. Progressive levels design was used to investigate the effects of single component environment( puerarin,baicalin,and glycyrrhizic acid); double-component environment( puerarin + baicalin,puerarin +glycyrrhizic acid,baicalin + glycyrrhizic acid); and triple-component environment( puerarin + baicalin + glycyrrhizic acid) on IDR of berberine,laying a foundation for further researches on the absorption mechanism of multiple components.

关键词(KeyWords): 小檗碱;特性溶出速率;中药生物药剂学分类系统
berberine;intrinsic dissolution rate;biopharmaceutics classification system of Chinese materia medica

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基金项目(Foundation): 国家自然科学基金项目(81473362)

作者(Author): 尹秀文;王子禹;潘孟;张鑫;王静;李彦萍;董玲;
YIN Xiu-wen;WANG Zi-yu;PAN Meng;ZHANG Xin;WANG Jing;LI Yan-ping;DONG Ling;Beijing University of Chinese Medicine;

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