中国中药杂志

2011, v.36(16) 2196-2199

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醒脑静微乳的体外释放研究
Study on in virto release of Xingnaojing microemulsion

王珊;杜守颖;陆洋;陈晓兰;宋逍;李冬雪;
WANG Shan1,DU Shouying1,LU Yang1,CHEN Xiaolan1,SONG Xiao1,LI Dongxue2(1.School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100102,China; 2.China National Center for Biotechnology Development,Beijing 100039,China)

摘要(Abstract):

目的:研究醒脑静微乳体外释放的特性,探讨其释药机制。方法:采用HPLC测定栀子苷含量,GC测定龙脑含量,以透析法研究醒脑静微乳的体外释放并利用药物释放模型方程拟合释放曲线。结果:微乳中水溶性成分栀子苷2 h内基本释放完全,释放符合Weibell方程,脂溶性成分龙脑释放符合一级方程。结论:微乳中不同性质的药物成分释放行为存在较大差异,各成分分布于微乳的不同相中。
Objective: To study in vitro release of Xingnaojing microemulsion and to investigate the release mechanism.Method: The concentration of jasminoidin was determined by HPLC and the concentration of Aipian was determined by GC.In vitro release characteristics were conducted by dialysis technique.Model fitting was used to determine the kinetics and mechanism.Result: Jasminoidin released completely within 2 h,fitting the Weibell model best.The release of borneol fitted first order model.Conclusion: The release mechanisms of different types of medicines are quite different.The different types of medicines dissolve in the different phases in the microemulsion.

关键词(KeyWords): 微乳;醒脑静;体外释放
microemulsion;Xingnaojing;in virto release

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基金项目(Foundation): 国家自然科学基金面上项目(81073057);; 国家“重大新药创制”科技重大专项(2009ZX09502-008,2009ZX09308-003);; 教育部博士点基金项目(20090013110007)

作者(Author): 王珊;杜守颖;陆洋;陈晓兰;宋逍;李冬雪;
WANG Shan1,DU Shouying1,LU Yang1,CHEN Xiaolan1,SONG Xiao1,LI Dongxue2(1.School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100102,China; 2.China National Center for Biotechnology Development,Beijing 100039,China)

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