中国中药杂志

2014, v.39(02) 230-234

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提取动力学模型的简化及黄芩总黄酮模型适应性研究
Study on simplification of extraction kinetics model and adaptability of total flavonoids model of Scutellariae Radix

陈杨;张晋;倪健;董晓旭;徐梦洁;豆浩然;申明睿;杨博迪;付京;
CHEN Yang;ZHANG Jin;NI Jian;DONG Xiao-xu;XU Meng-jie;DOU Hao-ran;SHEN Ming-rui;YANG Bo-di;FU Jing;School of Chinese Material Medica,Beijing University of Chinese Medicine;

摘要(Abstract):

由于中药材饮片存在形状不规则的问题,故该文对先前推导的中药通用提取动力学模型进行了简化,将公式中较难确定的药材粒径这一参数融合在最终参数a中。减少药材粒径的直接测定能够增加模型的准确性,扩大模型的适用范围,并且和实际生产情况更加接近,最终建立了简化后的模型公式以及相应的实验方法和数据处理方法。并以黄芩中总黄酮为测定指标,对水煎煮法提取黄芩中总黄酮对该模型的适应性进行了研究。研究发现,黄芩总黄酮质量浓度的自然对数值随时间、溶剂倍量值的自然对数变化成良好线性关系,通过计算,拟合,成功地建立了水煎煮法提取黄芩总黄酮的动力学模型,并对该模型进行了验证,拟合度良好,偏差能够很好地控制在工业生产要求的范围内,说明该方法的模型适应性良好。
Because of irregular shapes of Chinese herbal pieces,we simplified the previously deduced general extraction kinetic model for TCMs,and integrated particle diameters of Chinese herbs that had been hard to be determined in the final parameter " a". The reduction of the direct determination of particle diameters of Chinese herbs was conducive to increase the accuracy of the model, expand the application scope of the model,and get closer to the actual production conditions. Finally,a simplified model was established,with its corresponding experimental methods and data processing methods determined. With total flavonoids in Scutellariae Radix as the determination index,we conducted a study on the adaptability of total flavonoids extracted from Scutellariae Radix with the water decoction method in the model. The results showed a good linear correlation among the natural logarithm value of the mass concentration of total flavonoids in Scutellariae Radix,the time and the changes in the natural logarithm of solvent multiple. Through calculating and fitting,efforts were made to establish the kinetic model of extracting total flavonoids from Scutellariae Radix with the water decoction method,and verify the model,with a good degree of fitting and deviation within the range of the industrial production requirements. This indicated that the model established by the method has a good adaptability.

关键词(KeyWords): 模型简化;提取动力学;黄芩;总黄酮;适应性
model simplification;extraction dynamics;Scutellariae Radix;total flavonoids;adaptability

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(81173563)

作者(Authors): 陈杨;张晋;倪健;董晓旭;徐梦洁;豆浩然;申明睿;杨博迪;付京;
CHEN Yang;ZHANG Jin;NI Jian;DONG Xiao-xu;XU Meng-jie;DOU Hao-ran;SHEN Ming-rui;YANG Bo-di;FU Jing;School of Chinese Material Medica,Beijing University of Chinese Medicine;

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