中国中药杂志

2013, v.38(06) 909-913

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荜茇有效部位群的调血脂研究
Studies of effective part group of piperine to regulating lipid

包雪梅;那生桑;陆景坤;
BAO Xue-mei1,NA Sheng-sang2*,LU Jing-kun2(1.Department of Ent & HN Surgery,International Mongolian Hospital Hohhot,Hohhot 010065,China; 2.Mongolian Medicine Research Institute,Inner Mongolia Medidal University Hohhot,Hohhot 010010,China)

摘要(Abstract):

研究荜茇有效部位群对高脂血症的影响。将SD大鼠、金黄地鼠及昆明小鼠均分为空白组、模型组、阳性组和受试组,空白组饲喂普通饲料,其他组饲喂高脂饲料(小鼠实验腹腔注射蛋黄乳),每天依次灌胃給予相应浓度的赋形剂、赋形剂、辛伐他汀、荜茇有效部位群乳剂,一定时期后测定动物血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)及肝脏TC,TG的含量,以反映荜茇有效部位群的调血脂功能。结束后,与空白组比较,成功造成SD大鼠(TC升高)、小鼠(TC,TG,LDL升高),地鼠(TC,TG,LDL升高,HDL降低)高脂血症模型(P<0.05,P<0.001);与模型组比较,荜茇有效部位群既能降低血清TC,TG,LDL(P<0.05,P<0.001)和肝脏TC,TG含量,又能升高血清HDL含量(P<0.05,P<0.001)。从而证明荜茇有效部位群具有显著调节血脂功能,金黄地鼠为造高脂血症模型较理想的动物。
The effects of effective part group on hyperlipidemia in animal were studied.The SD rats,hamsters and Kunming mouse were divided into blank group,model group.The positive control group and test group were fed with normal diet,blank and other groups were fed with high fat diet(mouse only a single intraperitoneal injection of egg yolk).The corresponding concentration of solvent,simvastatin,effective part group of emulsion were given gavage once daily.The animal serum total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL),high density lipoprotein(HDL) and liver TC,TG contents were determined to observe the effects of the effective fractions on blood lipid regulating function.Comparing with control group,the animial hyperlipidemia models of the SD rat(TC increase),mouse(TC,TG,LDL increase),hamsters(TC,TG,LDL increase,HDL decrease)(P<0.05,P<0.001) were successfully established.Piper longum effective part group could decrease the serum TC,TG,LDL(P<0.05,P<0.001) and liver TC,TG content,and elevate serum HDL levels(P<0.05,P<0.001).The golden hamster is ideal for hyperlipidemia model.

关键词(KeyWords): 荜茇有效部位群;高脂血症;血脂;肝脂;动物模型
effective part group of piperine;hyperlipidemia;blood lipid;liver lipid;animal model

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基金项目(Foundation): 内蒙古自然科学基金项目(200208020603)

作者(Author): 包雪梅;那生桑;陆景坤;
BAO Xue-mei1,NA Sheng-sang2*,LU Jing-kun2(1.Department of Ent & HN Surgery,International Mongolian Hospital Hohhot,Hohhot 010065,China; 2.Mongolian Medicine Research Institute,Inner Mongolia Medidal University Hohhot,Hohhot 010010,China)

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