中国中药杂志

2014, v.39(03) 357-362

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整合药理学:中药现代研究新模式
Integrative pharmacology:new paradigm of modernization of Chinese medicine

许海玉;杨洪军;
XU Hai-yu;YANG Hong-jun;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;

摘要(Abstract):

中药方剂是中医临床治疗的主要形式和手段,探索中药方剂的化学物质实体与机体生命活动的交互规律,是中药研究的关键科学问题之一。在当前研究中,中药方剂研究存在整体与局部脱节、宏观与微观脱节、体内过程与活性评价脱节,为此,该文提出了整合药理学,从多层次、多环节对中药方剂与机体的相互作用关系进行系统解析,从而揭示中药方剂物质实体与生命活动的交互规律,形成中药现代研究的新模式,促进组合药物的发展。
Chinese medicinal formulae( CMF) were often used in the clinics of traditional Chinese medicine( TCM) which were critical for modernization of Chinese medicine to shed light on the interaction between CMF and biological organisms.In current studies,correlation between system and part,macroscopic actions and microcosmic mechanism,ADME process and pharmacologic actions were often neglected.Thus,we put forward integrative pharmacology,which could integrate the correlation between CMF and biological organisms from multi-levels and multi-dimensional views.Integrative pharmacology would reveal the molecular mechanism of CMF for ailments treatment and screen out effective material systematically,which would be the new paradigm of TCM research.

关键词(KeyWords): 整合药理学;中药方剂;方剂作用原理;中药现代化
integrative pharmacology;Chinese medicinal formulae;the molecular mechanism of Chinese medicinal formulae;modernization of Chinese medicine

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学青年基金项目(81202793);; 中国中医科学院自主选题项目(Z02063)

作者(Author): 许海玉;杨洪军;
XU Hai-yu;YANG Hong-jun;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;

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