中国中药杂志

2012, v.37(17) 2548-2553

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γ-巯丙基键合硅胶脱除龙胆提取液中的镉
Removal of cadmium from extracts of Gentianae Radix et Rhizoma by γ-mercaptopropyl-modified silica gel

陈两绵;邝才志;高慧敏;张启伟;王智民;朱晶晶;鲁艳清;
CHEN Liang-mian1,2,KUANG Cai-zhi1,3,GAO Hui-min1,2,ZHANG Qi-wei1,2,WANG Zhi-min1,2, ZHU Jing-jing1,2,LU Yan-qing1,4(1.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China; 2.National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines,Beijing 100700,China; 3.School of Traditional Chinese Medicine,Capital Medical University,Beijing 100069,China; 4.Pharmacy College,Henan University of Traditional Chinese Medicine,Zhengzhou

摘要(Abstract):

目的:研究γ-巯丙基键合硅胶(MPS)脱除龙胆提取液中镉(Cd)的最佳工艺,并对其脱镉性能进行评价。方法:采用静态吸附和动态吸附的方式考察镉的脱除率,并以镉脱除率、含固量、HPLC指纹图谱等指标综合评价MPS的脱镉性能。结果:静态吸附的工艺参数:药液浓度相当于0.20 g(药材).mL-1,吸附时间为120 min,药材量-MPS 15∶1;动态吸附的工艺参数:径高比为1∶3.5,药液浓度相当于0.20 g(药材).mL-1,药液流速0.9 mL.min-1,药材量-MPS 50∶1;龙胆药液脱镉前后的含固量及HPLC指纹图谱无显著性差异。结论:γ-巯丙基键合硅胶(MPS)能有效地脱除龙胆药液中的镉,脱镉性能良好。
Objective: To study the optimum process of removing cadmium irons from extracts of Gentianae Radix et Rhizoma with γ-mercaptopropyl-modified silica gel(MPS) and assess its cadmium ion-removing property.Method: Static and dynamic adsorptions were adopted to detect the cadmium-removing rate.MPS′ cadmium ion-removing property was assessed with such indicators as the cadmium-removing rate,the solid content and the HPLC fingerprint.Result: The process parameters of the static adsorption were as follows: 0.20 g·mL-1 of concentration of extracts,120 minutes of adsorption time and 15∶1 between raw materials and MPS.The process parameters of the dynamic adsorption were as follows: 1∶3.5 times between diameter and height,0.20 g·mL-1 of concentration of extracts,0.9 mL·min-1 of flow rate of the extracts and 50∶1 between raw materials and MPS.Before and after the cadmium ion-removing process,the extracts showed no notable difference in solid content and HPLC fingerprint.Conclusion: γ-mercaptopropyl-modified silica gel(MPS) can effectively remove cadmium ion from the extracts of Gentianae Radix et Rhizoma with an excellent cadmium ion-removing property.

关键词(KeyWords): γ-巯丙基键合硅胶;龙胆;重金属;镉
γ-mercaptopropyl modified silica gel(MPS);Gentianae Radix et Rhizoma;heavy metal;cadmium

Abstract:

Keywords:

基金项目(Foundation): 国家“重大新药创制”科技重大专项(2009ZX09308-003,2009ZX09301-005);; 中国中医科学院自主选题研究项目(ZZ20090201)

作者(Author): 陈两绵;邝才志;高慧敏;张启伟;王智民;朱晶晶;鲁艳清;
CHEN Liang-mian1,2,KUANG Cai-zhi1,3,GAO Hui-min1,2,ZHANG Qi-wei1,2,WANG Zhi-min1,2, ZHU Jing-jing1,2,LU Yan-qing1,4(1.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China; 2.National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines,Beijing 100700,China; 3.School of Traditional Chinese Medicine,Capital Medical University,Beijing 100069,China; 4.Pharmacy College,Henan University of Traditional Chinese Medicine,Zhengzhou

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