刘睿;刘志东;舒乐新;章臣桂;张伯礼;
LIU Rui1,LIU Zhidong1,SHU Lexin1,ZHANG Chengui2,ZHANG Boli1(1.Tianjin University of Traditional Chinese Medicine,Engineering Research Center of Modern Chinese MedicineDiscovery and Preparation Technique,Ministry of Education,Tianjin 300193,China;2.Tianjin Zhongxin Pharmaceutics Engineering Center,Tianjin 300193,China)

• 1:天津中医药大学现代中药发现与制剂技术教育部工程研究中心
• 2:天津中新药业技术中心

摘要(Abstract)：

目的:研究辛酸癸酸聚乙二醇甘油酯(labrasol,Lab),聚乙二醇硬脂酸酯15(solutol HS 15,Sol),二乙二醇单乙基醚(transcutol P,Trans)对芒果苷离体角膜透过率的影响。方法:采用离体扩散实验考察不同体积分数的3种渗透促进剂对芒果苷角膜透过率的影响。结果:Lab体积分数为1.0%,1.5%,2.0%,3.0%时,芒果苷的角膜表观渗透系数分别增加了1.80,3.27,3.41,4.76倍;Sol体积分数为0.2%,0.4%时,芒果苷的角膜表观渗透系数分别增加了1.98,3.07倍,与对照组相比均具有显著性差异(P<0.01),Trans体积分数为0.01%⁰.03%时,芒果苷的角膜表观渗透系数并未增加。结论:Lab体积分数为1.0%0.03%时,芒果苷的角膜表观渗透系数并未增加。结论:Lab体积分数为1.0%³.0%,Sol体积分数为0.2%3.0%,Sol体积分数为0.2%⁰.4%时,显著增加芒果苷的角膜表观渗透系数,而Trans体积分数为0.01%0.4%时,显著增加芒果苷的角膜表观渗透系数,而Trans体积分数为0.01%⁰.03%时,不能增加芒果苷的角膜表观渗透系数。
Objective: To investigate the effects of labrasol,solutol HS 15 and transcutol P on the corneal permeability of mangiferin in vitro.Method: The effects of three penetration enhancers on the corneal permeability of mangiferin were investigated in vitro by using isolated rabbit corneas.Result: The apparent Papp enhancements were increased 1.80,3.27,3.41 and 4.76-folds with Lab at 1.0%,1.5%,2.0% and 3.0%(P<0.01),respectively.The apparent Papp increased 1.98 and 3.07-folds with Sol at 0.2% and 0.4%(P<0.01),respectively,but reduced with 0.01%-0.03% Trans.Conclusion: The Papp value of mangiferin is significantly enhanced by 1.0%-3.0%Lab,0.2% and 0.4% Sol,however the Papp value of mangiferin is reduced by 0.01%-0.03% Trans.

关键词(KeyWords)： labrasol;solutol HS15;transcutol P;芒果苷;角膜透过;渗透促进剂
labrasol;solutol HS 15;transcutol P;mangiferin;corneal permeability;penetration enhancer

Abstract:

Keywords:

基金项目(Foundation): 国家重点基础研究发展计划(973计划)项目(2005CB523404);; 国家科技支撑计划项目(2007BAI47B01);; 教育部科学技术研究重点项目(209002);; 国际科技合作项目(2007DFC31670)

作者(Authors): 刘睿;刘志东;舒乐新;章臣桂;张伯礼;
LIU Rui1,LIU Zhidong1,SHU Lexin1,ZHANG Chengui2,ZHANG Boli1(1.Tianjin University of Traditional Chinese Medicine,Engineering Research Center of Modern Chinese MedicineDiscovery and Preparation Technique,Ministry of Education,Tianjin 300193,China;2.Tianjin Zhongxin Pharmaceutics Engineering Center,Tianjin 300193,China)

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