中国中药杂志

2006, (07) 574-577

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狭基线纹香茶菜对四氯化碳所致大鼠急性肝损伤的保护作用
Protective effect of Isodon lophanthoides var.gerardianus on acute hepatic injury induced by carbon tetrachloride in rats

长尾由纪子;叶木荣;林朝展;祝晨蔯;赖小平;
NAGAO Yukiko,YE Mu-rong,LIN Chao-zhan,ZHU Chen-chen,LAI Xiao-ping(New Drug Research and Development Center,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China)

摘要(Abstract):

目的:研究狭基线纹香茶菜对四氯化碳(CCl4)所致大鼠急性肝损伤的保护作用。方法:60只大鼠随机分为正常组、模型组、高、中、低剂量给药组、阳性药对照组6个组。给药组按15,7.5,3.75 g.kg-1剂量,以狭基线纹香茶菜水提物灌胃;阳性药对照组按45 mg.kg-1给联苯双酯;每天1次,连续10天。给药第1,4,7,10天(共4次),模型组和给药组按2 mL.kg-1腹腔注射10%CCl4造模。第11天,末次给药24 h后,取血,测定血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)及总胆红素(T-Bil),同时测体重、肝脏重、脾重和胸腺重,求脏器系数,并取肝组织作病理观察。结果:狭基线纹香茶菜可显著降低急性肝损伤大鼠血清ALT,AST,ALP水平和T-Bil含量,对肝重量增大和胸腺萎缩有抑制作用。病理检查结果也显示有明显的保肝作用。结论:狭基线纹香茶菜对CCl4所致大鼠急性肝损伤有保护作用。
Objective: To study the protective effects of Isodon lophanthoides var.gerardianus(ILVG) aqueous extract on the acute hepatic injury induced by carbon tetrachloride(CCl_(4)) in rats.Method: Sixty rats were allocated into control group,model group,low,middle and high dosage group and Bifendate group randomly.At the test group,rats received either ILVG aqueous extract(15,7.5,3.75 g·kg~(-1)) or Bifendate(45 mg·kg~(-1)) by gastric perfusion daily for 10 consecutive days.In 1st,4 th,7 th and 10 th days,10% CCl_(4)(2 mL·kg~(-1)) was given to rats by intraperitoneal(ip) injection.The rats were killed 24 h after the last adminiction with drug,the levels of ALT,AST,ALP and total bilirubin in serum were analyzed,the body weight,liver weight,spleen weight and thymus weight of each rat were measured,and the hepatic tissue pathology was observed.Result: ILVG could decrease the ALT,AST,ALP and T-Bil in serum,restrain the enlargement of liver and the shrinkage of thymus,and reduce the necrosis in pathological observation.Conclusion: ILVG aqueous extract possesses the effects of protecting on the acute hepatic injury induced by CCl_(4)in rats.

关键词(KeyWords): 狭基线纹香茶菜;CCl4;急性肝损伤
Isodon lophanthoides var.gerardianus;carbon tetrachloride;acute liver injury

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基金项目(Foundation): 广东省自然科学基金项目(970217)

作者(Author): 长尾由纪子;叶木荣;林朝展;祝晨蔯;赖小平;
NAGAO Yukiko,YE Mu-rong,LIN Chao-zhan,ZHU Chen-chen,LAI Xiao-ping(New Drug Research and Development Center,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China)

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