中国中药杂志

2009, v.34(09) 1063-1066

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探讨道地药材研究的模式生物及模型
Discuss on model organism and model for geoherbs' study

黄璐琦;戴住波;吕冬梅;袁媛;
HUANG Luqi,DAI Zhubo,LV Dongmei,YUAN Yuan(Institute of Chinese Material Medica,China Academy of Chinese Material Science,Beijing 10070,China)

摘要(Abstract):

道地药材的物质属性是道地药材科学内涵的根本。生物学角度认为道地药材的表型包括药材性状、组织结构、有效成分的组成和含量及其疗效等,其取决于道地药材原植物的基因型及其所处的环境,即"表型=基因型+环境饰变"。为这一假说能得到科学的诠释,作者探讨了以丹参Salvia miltiorrhiza为材料建立可控的研究模型以及树立丹参为模式植物的思路与方法来研究道地药材生物学成因的可行性。
The scientific essence of geoherbs bases on the attribute of matter.The phenotype of geoherbs from biological point view includes medicinal character,tissue structure,content and composition of the effective components and the therapeutic effect.The forming of geoherb is resulted from the interaction of genotype and environment.It can be expressed by the formula: phenotype=genotype + environmental modification.In order to prove this hypothesis,the authors discussed the model organism and model for geoherbs′ study based on Salvia miltiorrhiza.

关键词(KeyWords): 道地药材;物质属性;研究模型;模式生物;丹参
geoherbs;attribute of matter;model;model organism;Salvia miltiorrhiza

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基金项目(Foundation): 国家重点基础研究发展计划(973)项目(2006CB504700);; 国家高技术研究发展计划(863)项目(2007AA02Z104)

作者(Author): 黄璐琦;戴住波;吕冬梅;袁媛;
HUANG Luqi,DAI Zhubo,LV Dongmei,YUAN Yuan(Institute of Chinese Material Medica,China Academy of Chinese Material Science,Beijing 10070,China)

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