中国中药杂志

2020, v.45(14) 3360-3368

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道地牡丹皮的无机元素组成特征及与其他产地的差异性比较分析研究
Comparative analysis and study on component characteristics of inorganic elements in genuine Moutan Cortex and their differences from other areas

朱毛毛;夏昀卿;封亮;贾晓斌;
ZHU Mao-mao;XIA Yun-qing;FENG Liang;JIA Xiao-bin;Nanjing Institute of Product Quality Inspection;School of Traditional Chinese Pharmacy, China Pharmaceutical University;School of Pharmacy, Jiangsu University;

摘要(Abstract):

基于"组分结构"理论对20批道地牡丹皮与12批非道地牡丹皮中17种无机元素的组成特征进行解析。建立了牡丹皮无机元素电感耦合等离子体质谱(ICP-MS)的分析方法,绘制了无机元素指纹图谱,并通过相关性分析及主成分分析,挖掘出牡丹皮无机元素组成特征的构成要素:特征元素砷(As)、铬(Cr)、铅(Pb)、硒(Se)、钾(K)、铜(Cu)与镉(Cd);分析了道地与非道地牡丹皮样品中构成要素之间的量和量比关系,发现道地统装牡丹皮特征元素质量分数量为0.33,1.42,1.33,0.11,4 385.78,4.87,0.49 mg·kg~(-1),量比关系1.00∶4.30∶4.03∶0.33∶13 290.24∶14.76∶1.48,道地分装牡丹皮特征元素质量分数为0.24,1.96,0.36,0.05,5 122.01,4.81,0.05 mg·kg~(-1),量比关系1.00∶8.17∶1.50∶0.21∶21 341.71∶20.04∶0.21。道地牡丹皮无机元素独特的组成特征,旨为牡丹皮药材的质量控制及安全性评价提供依据。
Based on the theory of "component structure", the component structure characteristics of 17 inorganic elements in 20 batches of genuine Moutan Cortex and 12 batches of non-genuine Moutan Cortex were analyzed. The analytical method of inductively coupled plasma mass spectrometry(ICP-MS) for inorganic elements in Moutan Cortex was established, and the fingerprint of inorganic elements was drawn. Through correlation analysis and principal component analysis, the constituent elements of inorganic elements in Moutan Cortex were excavated, namely characteristic elements As, Cr, Pb, Se, K, Cu and Cd. The amount and the quantity relative ratio between the components of genuine and non-genuine Moutan Cortex samples were analyzed. It was found that the amount of characteristic elements in the bulk genuine Moutan Cortex samples was 0.33, 1.42, 1.33, 0.11, 4 385.78, 4.87, 0.49 mg·kg~(-1), with the quantity relative ratio of 1.00∶4.30∶4.03∶0.33∶13 290.24∶14.76∶1.48. The amount of characteristic elements in sub-packaged genuine Moutan Cortex was 0.24, 1.96, 0.36, 0.05, 5 122.01, 4.81, 0.05 mg·kg~(-1), with the quantity relative ratio of 1.00∶8.17∶1.50∶0.21∶21 341.71∶20.04∶0.21. The unique structural characteristics of inorganic elements in genuine Moutan Cortex are studied to provide a basis for the quality control and safety evaluation of Moutan Cortex.

关键词(KeyWords): 牡丹皮;道地性;无机元素;组分组成特征
Moutan Cortex;genuine;inorganic element;structural characteristics of components

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基金项目(Foundation): 国家自然科学基金项目(81703775,81973536);; 中国药科大学双一流项目(CPU2018GF07,CPU2018GY11);; 国家重点研发计划项目(2018YFC1706900);; 河南宛西制药合作基金项目(8010020204)

作者(Author): 朱毛毛;夏昀卿;封亮;贾晓斌;
ZHU Mao-mao;XIA Yun-qing;FENG Liang;JIA Xiao-bin;Nanjing Institute of Product Quality Inspection;School of Traditional Chinese Pharmacy, China Pharmaceutical University;School of Pharmacy, Jiangsu University;

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