中国中药杂志

2015, v.40(18) 3585-3589

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Box-Behnken响应面法优化鼻鼽颗粒醇提浸膏喷雾干燥工艺研究
Optimization of spraying dry technology of Biqiu ranules ethanol extract by Box-Behnken response surface method

张艳军;刘莉莉;胡军华;吴云;晁恩祥;萧伟;
ZHANG Yan-jun;LIU Li-li;HU Jun-hua;WU Yun;CHAO En-xiang;XIAO Wei;Jiangsu Kanion Pharmaceutical Co.,Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;Department of Respiratory Medicine,China-Japan Friendship Hospital;

摘要(Abstract):

利用Box-Benhnken中心组合试验和响应面分析法,以进风温度、进料速度、药液比重为自变量,以五味子醇甲和牛蒡苷含量的综合评分为因变量,试验数据进行二项式拟合,建立综合评分指标与各自变量之间的数学关系,对鼻鼽颗粒醇提浸膏的喷雾干燥工艺进行优选。最佳喷雾干燥工艺为进风温度175℃,进料速度32 m L·min-1,药液比重1.10,在此条件下,鼻鼽颗粒醇提浸膏喷雾干燥的综合评分为92.68,与模型预测值(93.03)接近。建立的鼻鼽颗粒醇提浸膏喷雾干燥工艺条件切实可行,为工业化的生产提供了实验依据。
With inlet temperature,specific gravity,feeding speed as independent variables,the comprehensive evaluating indexes of content of schisandrin and arctiin as dependent variable,the experimental data were fitted to a second order polynomial equation. Based on establishing the mathematical relationship between the comprehensive evaluating indexes and respective variables,Box-Benhnken central composite test and response surface analysis method was employed to optimize the spray drying technology of Biqiu granules ethanol extract. The optimal drying parameter was as follows: the inlet temperature was 175 ℃,the specific gravity was 1. 10,feeding speed was 32 r· min- 1. Under these conditions,the comprehensive evaluating indexes of spraying dry processes was 92. 68,which was close to the model prediction. The spraying dry technology of Biqiu granules ethanol extract optimized by response surface methodology was accurate and feasible,which provided theoretical experiment basis for the industrialization production.

关键词(KeyWords): 鼻鼽颗粒;喷雾干燥;响应面法;Box-Behnken设计
Biqiu granules;response surface methodology;spraying dry;Box-Behnken design

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基金项目(Foundation): 国家“重大新药创制”科技重大专项(2013ZX09402203)

作者(Author): 张艳军;刘莉莉;胡军华;吴云;晁恩祥;萧伟;
ZHANG Yan-jun;LIU Li-li;HU Jun-hua;WU Yun;CHAO En-xiang;XIAO Wei;Jiangsu Kanion Pharmaceutical Co.,Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;Department of Respiratory Medicine,China-Japan Friendship Hospital;

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